Natural Dibenzo[b,f]oxepines, Pacharin and Bauhiniastatin-1, Isolated from Bauhinia acuruana Induce Apoptosis on Breast Cancer Cells via MCL-1 Protein Reduction.

Humans Female Bauhinia Breast Neoplasms / metabolism Leukocytes, Mononuclear / metabolism Myeloid Cell Leukemia Sequence 1 Protein / therapeutic use Antineoplastic Agents / pharmacology Apoptosis MCF-7 Cells Cell Line, Tumor Adenocarcinoma / drug therapy Leukemia

Journal

Planta medica
ISSN: 1439-0221
Titre abrégé: Planta Med
Pays: Germany
ID NLM: 0066751

Informations de publication

Date de publication:
Mar 2023
Historique:
pubmed: 28 7 2022
medline: 25 2 2023
entrez: 27 7 2022
Statut: ppublish

Résumé

Herein, we describe the antiproliferative effects of two natural dibenzo [

Identifiants

DOI: 10.1055/a-1910-5776 PMID: 35896509
pubmed: 35896509
doi: 10.1055/a-1910-5776
doi:

Substances chimiques

Myeloid Cell Leukemia Sequence 1 Protein 0
Antineoplastic Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

286-294

Subventions

Organisme : 1133-2.07/2012
ID : FACEPE
Organisme : FACEPE
ID : 1133-2.07/2012

Informations de copyright

Thieme. All rights reserved.

Déclaration de conflit d'intérêts

The authors declare that they have no conflict of interest.

Auteurs

Silvia de Maria Souza (SM)

Department of Physiology and Pharmacology, Biosciences Center, Federal University of Pernambuco, Recife-Pernambuco, Brazil.

Luciano Santos de Souza (LS)

Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador-Bahia, Brazil.

Valdenizia Rodrigues Silva (VR)

Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador-Bahia, Brazil.

Milena Botelho Pereira Soares (MBP)

Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador-Bahia, Brazil.
SENAI Institute for Innovation in Advanced Health Systems, SENAI CIMATEC, Salvador-Bahia, Brazil.

Daniel Pereira Bezerra (DP)

Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador-Bahia, Brazil.

Roberto Wagner da Silva Gois (RWDS)

Federal Institute of Ceara, Campus Acaraú, Acaraú-Ceara, Brazil.
Chemistry Postgraduate Program, Federal University of Ceara, Fortaleza-Ceara, Brazil.

Horlando Carlota da Silva (HCD)

Chemistry Postgraduate Program, Federal University of Ceara, Fortaleza-Ceara, Brazil.

Gilvandete Maria Pinheiro Santiago (GMP)

Chemistry Postgraduate Program, Federal University of Ceara, Fortaleza-Ceara, Brazil.
Department of Pharmacy, Federal University of Ceara, Fortaleza-Ceara, Brazil.

Gardenia Carmen Gadelha Militao (GCG)

Department of Physiology and Pharmacology, Biosciences Center, Federal University of Pernambuco, Recife-Pernambuco, Brazil.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Natural Dibenzo[b,f]oxepines, Pacharin and...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Fabaceae › Bauhinia › Natural Dibenzo[b,f]oxepines, Pacharin and...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Natural Dibenzo[b,f]oxepines, Pacharin and...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Natural Dibenzo[b,f]oxepines, Pacharin and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-bcl-2 › Protéine Mcl-1 › Natural Dibenzo[b,f]oxepines, Pacharin and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Natural Dibenzo[b,f]oxepines, Pacharin and...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Natural Dibenzo[b,f]oxepines, Pacharin and...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Cellules MCF-7 › Natural Dibenzo[b,f]oxepines, Pacharin and...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Natural Dibenzo[b,f]oxepines, Pacharin and...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Adénocarcinome › Natural Dibenzo[b,f]oxepines, Pacharin and...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Leucémies › Natural Dibenzo[b,f]oxepines, Pacharin and...