Dietary protein increases T-cell-independent sIgA production through changes in gut microbiota-derived extracellular vesicles.

Animals Dietary Proteins Extracellular Vesicles / metabolism Gastrointestinal Microbiome Immunoglobulin A, Secretory / metabolism Mice T-Lymphocytes / metabolism

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
27 07 2022
Historique:
received: 12 08 2020
accepted: 30 06 2022
entrez: 27 7 2022
pubmed: 28 7 2022
medline: 30 7 2022
Statut: epublish

Résumé

Secretory IgA is a key mucosal component ensuring host-microbiota mutualism. Here we use nutritional geometry modelling in mice fed 10 different macronutrient-defined, isocaloric diets, and identify dietary protein as the major driver of secretory IgA production. Protein-driven secretory IgA induction is not mediated by T-cell-dependent pathways or changes in gut microbiota composition. Instead, the microbiota of high protein fed mice produces significantly higher quantities of extracellular vesicles, compared to those of mice fed high-carbohydrate or high-fat diets. These extracellular vesicles activate Toll-like receptor 4 to increase the epithelial expression of IgA-inducing cytokine, APRIL, B cell chemokine, CCL28, and the IgA transporter, PIGR. We show that succinate, produced in high concentrations by microbiota of high protein fed animals, increases generation of reactive oxygen species by bacteria, which in turn promotes extracellular vesicles production. Here we establish a link between dietary macronutrient composition, gut microbial extracellular vesicles release and host secretory IgA response.

Identifiants

DOI: 10.1038/s41467-022-31761-y PMID: 35896537 PMC: PMC9329401
pubmed: 35896537
doi: 10.1038/s41467-022-31761-y
pii: 10.1038/s41467-022-31761-y
pmc: PMC9329401
doi:

Substances chimiques

Dietary Proteins 0
Immunoglobulin A, Secretory 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4336

Informations de copyright

© 2022. Crown.

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Auteurs

Jian Tan (J)

Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.

Duan Ni (D)

Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.

Jemma Taitz (J)

Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.

Gabriela Veronica Pinget (GV)

Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.

Mark Read (M)

Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
School of Computer Science, Faculty of Engineering, University of Sydney, Sydney, NSW, Australia.
ORCID: 0000-0002-1481-4780

Alistair Senior (A)

Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
School of Life and Environmental Sciences, Faculty of Science, University of Sydney, Sydney, NSW, Australia.
ORCID: 0000-0001-9805-7280

Jibran Abdul Wali (JA)

Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
School of Life and Environmental Sciences, Faculty of Science, University of Sydney, Sydney, NSW, Australia.
ORCID: 0000-0002-8524-5773

Reem Elnour (R)

Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
School of Life and Environmental Sciences, Faculty of Science, University of Sydney, Sydney, NSW, Australia.

Erin Shanahan (E)

Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
School of Life and Environmental Sciences, Faculty of Science, University of Sydney, Sydney, NSW, Australia.

Huiling Wu (H)

Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Kidney Node Laboratory, The Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
Renal Medicine, Royal Prince Alfred Hospital, Sydney, NSW, Australia.

Steven J Chadban (SJ)

Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Kidney Node Laboratory, The Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
Renal Medicine, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
ORCID: 0000-0002-0527-898X

Ralph Nanan (R)

Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Sydney Medical School Nepean, University of Sydney, Sydney, NSW, Australia.

Nicholas Jonathan Cole King (NJC)

Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Sydney Cytometry, The University of Sydney and The Centenary Institute, Sydney, NSW, Australia.
ORCID: 0000-0002-3877-9772

Georges Emile Grau (GE)

School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Vascular Immunology Unit, The University of Sydney, Sydney, NSW, Australia.
ORCID: 0000-0002-0442-0462

Stephen J Simpson (SJ)

Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
School of Life and Environmental Sciences, Faculty of Science, University of Sydney, Sydney, NSW, Australia.
ORCID: 0000-0003-0256-7687

Laurence Macia (L)

Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia. Laurence.macia@sydney.edu.au.
School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia. Laurence.macia@sydney.edu.au.
Sydney Cytometry, The University of Sydney and The Centenary Institute, Sydney, NSW, Australia. Laurence.macia@sydney.edu.au.
ORCID: 0000-0003-0835-851X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Dietary protein increases T-cell-independent...
questionsmedicales.fr › Aliments et boissons › Aliments › Protéines alimentaires › Dietary protein increases T-cell-independent...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Vésicules extracellulaires › Dietary protein increases T-cell-independent...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Dietary protein increases T-cell-independent...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline A › Immunoglobuline A sécrétoire › Dietary protein increases T-cell-independent...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Dietary protein increases T-cell-independent...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Dietary protein increases T-cell-independent...