Evaluation of tau deposition using
Alzheimer’s disease
Amyloid-beta
Florbetaben
Mild cognitive impairment
PI-2620
Tau
Journal
Alzheimer's research & therapy
ISSN: 1758-9193
Titre abrégé: Alzheimers Res Ther
Pays: England
ID NLM: 101511643
Informations de publication
Date de publication:
27 07 2022
27 07 2022
Historique:
received:
11
04
2022
accepted:
11
07
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
30
7
2022
Statut:
epublish
Résumé
The ability of Subjects with a diagnosis of MCI due to AD or mild AD dementia and a visually amyloid-positive Percentage of visually tau-positive scans increased with amyloid-beta deposition measured in The findings support the hypothesis that Data used in this manuscript belong to a tau PET imaging sub-study of the elenbecestat MissionAD Phase 3 program registered in ClinicalTrials.gov ( NCT02956486 ; NCT03036280 ).
Sections du résumé
BACKGROUND
The ability of
METHODS
Subjects with a diagnosis of MCI due to AD or mild AD dementia and a visually amyloid-positive
RESULTS
Percentage of visually tau-positive scans increased with amyloid-beta deposition measured in
CONCLUSIONS
The findings support the hypothesis that
TRIAL REGISTRATION
Data used in this manuscript belong to a tau PET imaging sub-study of the elenbecestat MissionAD Phase 3 program registered in ClinicalTrials.gov ( NCT02956486 ; NCT03036280 ).
Identifiants
pubmed: 35897078
doi: 10.1186/s13195-022-01048-x
pii: 10.1186/s13195-022-01048-x
pmc: PMC9327167
doi:
Substances chimiques
((18)F)PI-2620
0
Amyloid
0
Amyloid beta-Peptides
0
Biomarkers
0
Fluorine Radioisotopes
0
Pyridines
0
tau Proteins
0
Banques de données
ClinicalTrials.gov
['NCT03036280', 'NCT02956486']
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105Informations de copyright
© 2022. The Author(s).
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