Epigenetics may characterize asymptomatic COVID-19 infection.
COVID-19
Epigenetics
Methylation
SARS-CoV-2
Journal
Human genomics
ISSN: 1479-7364
Titre abrégé: Hum Genomics
Pays: England
ID NLM: 101202210
Informations de publication
Date de publication:
27 07 2022
27 07 2022
Historique:
received:
04
01
2022
accepted:
01
07
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
30
7
2022
Statut:
epublish
Résumé
RT-PCR is the foremost clinical test for diagnosis of COVID-19. Unfortunately, PCR-based testing has limitations and may not result in a positive test early in the course of infection before symptoms develop. Enveloped RNA viruses, such as coronaviruses, alter peripheral blood methylation and DNA methylation signatures may characterize asymptomatic versus symptomatic infection. We used Illumina's Infinium MethylationEPIC BeadChip array to profile peripheral blood samples from 164 patients who tested positive for SARS-CoV-2 by RT-PCR, of whom 8 had no symptoms. Epigenome-wide association analysis identified 10 methylation sites associated with infection and a quantile-quantile plot showed little inflation. These preliminary results suggest that differences in methylation patterns may distinguish asymptomatic from symptomatic infection.
Identifiants
pubmed: 35897116
doi: 10.1186/s40246-022-00401-3
pii: 10.1186/s40246-022-00401-3
pmc: PMC9327394
doi:
Types de publication
Letter
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
27Subventions
Organisme : NHLBI NIH HHS
ID : F32 HL160123
Pays : United States
Organisme : NHLBI NIH HHS
ID : 1F32HL160123
Pays : United States
Organisme : NIH HHS
ID : CTSI TR001082
Pays : United States
Informations de copyright
© 2022. The Author(s).
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