Nucleoside Transport and Nucleobase Uptake Null Mutants in
Aspergillus nidulans
FurD uracil transporter
Trichomonas vaginalis
Trypanosoma cruzi
equilibrative nucleoside transporter
expression system
nucleobase transport
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 Jul 2022
23 Jul 2022
Historique:
received:
23
06
2022
revised:
05
07
2022
accepted:
20
07
2022
entrez:
28
7
2022
pubmed:
29
7
2022
medline:
30
7
2022
Statut:
epublish
Résumé
The study of transporters is highly challenging, as they cannot be isolated or studied in suspension, requiring a cellular or vesicular system, and, when mediated by more than one carrier, difficult to interpret. Nucleoside analogues are important drug candidates, and all protozoan pathogens express multiple equilibrative nucleoside transporter (ENT) genes. We have therefore developed a system for the routine expression of nucleoside transporters, using CRISPR/cas9 to delete both copies of all three nucleoside transporters from
Identifiants
pubmed: 35897714
pii: ijms23158139
doi: 10.3390/ijms23158139
pmc: PMC9331716
pii:
doi:
Substances chimiques
Equilibrative Nucleoside Transport Proteins
0
Membrane Transport Proteins
0
Nucleosides
0
Purines
0
Pyrimidines
0
Uracil
56HH86ZVCT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Council for Scientific and Technological Development
ID : 206385/2014-5
Organisme : Saudi Arabian government
ID : PhD studentship (2)
Organisme : Libyan government
ID : PhD studentship (2)
Organisme : Wellcome Trust
ID : Institutional Strategic Support Fund (ISSF) Award (ref 317019)
Pays : United Kingdom
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