Infectious Complications of DiGeorge Syndrome in the Setting of Malignancy.
22q11.2 deletion syndrome
digeorge syndrome
hodgkin’s lymphoma
immunodeficiency
infectious disease
lymphopenia
t-cell deficiency
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
accepted:
24
06
2022
entrez:
28
7
2022
pubmed:
29
7
2022
medline:
29
7
2022
Statut:
epublish
Résumé
This report describes a case of a young man with DiGeorge Syndrome, repaired Tetralogy of Fallot, relapsed metastatic Hodgkin's Lymphoma, immunodeficiency, and a history of recurrent and severe infections. A review of the literature indicates that patients with DiGeorge Syndrome are at greater risk for infection, malignancy, and cardiac events due to anatomic and immunologic complications resulting from a deletion in the 22q11.2 chromosome. As an increased number of patients with DiGeorge Syndrome are surviving into adulthood, it is important to understand the progression of the disease and the long-term implications associated with variable degrees of thymic hypoplasia and immune deficiency.
Identifiants
pubmed: 35898360
doi: 10.7759/cureus.26277
pmc: PMC9308940
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e26277Informations de copyright
Copyright © 2022, Hare et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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