Renal Amyloidosis: Epidemiological, Clinical, and Laboratory Profile in Adults from One Nephrology Center.
Journal
International journal of nephrology
ISSN: 2090-214X
Titre abrégé: Int J Nephrol
Pays: United States
ID NLM: 101546753
Informations de publication
Date de publication:
2022
2022
Historique:
received:
01
03
2022
revised:
13
06
2022
accepted:
29
06
2022
entrez:
28
7
2022
pubmed:
29
7
2022
medline:
29
7
2022
Statut:
epublish
Résumé
Renal amyloidosis is one of the main differential diagnoses of nephrotic proteinuria in adults and the elderly. The aim of this study with the most important series in our country is to contribute to the epidemiological, clinical, and etiological study of the renal amyloidosis. In a retrospective study carried out between 1975 and 2019, 310 cases of histologically proven and typed renal amyloidosis were selected for this study. There were 209 men and 101 women with a mean age of 53.8 ± 15.4 years (range, 17-84 years). Of the 310 cases, 255 (82.3%) were diagnosed with AA renal amyloidosis and 55 (17.7%) with non-AA amyloidosis. Infections were the main cause of AA amyloidosis, and tuberculosis was the most frequent etiology. The period from the onset of the underlying disease to diagnosis of the renal amyloidosis was an average of 177 months. The most frequent manifestations at the time of diagnosis were nephrotic syndrome (84%), chronic renal failure (30.3%), and end-stage renal disease (37.8%). After a medium follow-up of 16 months (range, 0-68 months), mortality occurred in 60 cases. Given the high frequency of AA amyloidosis in our country, awareness of the proper management of infectious and chronic inflammatory diseases remains a priority in reducing the occurrence of this serious disease.
Sections du résumé
Background
UNASSIGNED
Renal amyloidosis is one of the main differential diagnoses of nephrotic proteinuria in adults and the elderly. The aim of this study with the most important series in our country is to contribute to the epidemiological, clinical, and etiological study of the renal amyloidosis.
Methods
UNASSIGNED
In a retrospective study carried out between 1975 and 2019, 310 cases of histologically proven and typed renal amyloidosis were selected for this study.
Results
UNASSIGNED
There were 209 men and 101 women with a mean age of 53.8 ± 15.4 years (range, 17-84 years). Of the 310 cases, 255 (82.3%) were diagnosed with AA renal amyloidosis and 55 (17.7%) with non-AA amyloidosis. Infections were the main cause of AA amyloidosis, and tuberculosis was the most frequent etiology. The period from the onset of the underlying disease to diagnosis of the renal amyloidosis was an average of 177 months. The most frequent manifestations at the time of diagnosis were nephrotic syndrome (84%), chronic renal failure (30.3%), and end-stage renal disease (37.8%). After a medium follow-up of 16 months (range, 0-68 months), mortality occurred in 60 cases.
Conclusions
UNASSIGNED
Given the high frequency of AA amyloidosis in our country, awareness of the proper management of infectious and chronic inflammatory diseases remains a priority in reducing the occurrence of this serious disease.
Identifiants
pubmed: 35898389
doi: 10.1155/2022/8493479
pmc: PMC9314002
doi:
Types de publication
Journal Article
Langues
eng
Pagination
8493479Informations de copyright
Copyright © 2022 Hayet Kaaroud et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
Références
Virchows Arch A Pathol Anat Histopathol. 1988;412(3):197-204
pubmed: 3124341
Pathology. 1986 Jan;18(1):137-40
pubmed: 2425332
JACC Cardiovasc Imaging. 2020 Jun;13(6):1368-1383
pubmed: 31607664
Hum Pathol. 1997 Jul;28(7):847-9
pubmed: 9224755
Intern Med. 2011;50(21):2511-7
pubmed: 22041350
Kidney Int. 2013 Mar;83(3):463-70
pubmed: 23302715
Kidney Int. 2008 Jul;74(2):218-22
pubmed: 18449172
J Nephropathol. 2015 Jan;4(1):7-12
pubmed: 25657979
Circulation. 2003 May 20;107(19):2440-5
pubmed: 12719281
Amyloid. 2005 Jun;12(2):75-87
pubmed: 16011983
JAMA. 2020 Jul 7;324(1):79-89
pubmed: 32633805
Best Pract Res Clin Rheumatol. 2003 Dec;17(6):909-27
pubmed: 15123043
Philos Trans R Soc Lond B Biol Sci. 2001 Feb 28;356(1406):203-10; discussion 210-1
pubmed: 11260801
Blood. 2015 Apr 2;125(14):2239-44
pubmed: 25636337
Semin Arthritis Rheum. 2007 Jun;36(6):397-401
pubmed: 17276496
Clin J Am Soc Nephrol. 2013 Sep;8(9):1515-23
pubmed: 23704299
J Rheumatol. 2004 Jun;31(6):1139-42
pubmed: 15170927
Nephrol Ther. 2010 Jun;6(3):173-8
pubmed: 20399171
Amyloid. 2017 Sep;24(3):162-166
pubmed: 28686088
Am J Hematol. 2012 May;87(5):465-71
pubmed: 22389105
Nephrol Ther. 2017 Jun;13(4):258-264
pubmed: 28462876
Ecancermedicalscience. 2020 Dec 15;14:1156
pubmed: 33574901
Saudi J Kidney Dis Transpl. 2013 Sep;24(5):950-8
pubmed: 24029260
Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16115-20
pubmed: 23959890
Medicine (Baltimore). 1991 Jul;70(4):246-56
pubmed: 2067409
J Clin Pathol. 1966 Nov;19(6):539-48
pubmed: 5953729
Bull Acad Natl Med. 2006 Feb;190(2):403-16; discussion 416-8
pubmed: 17001869
QJM. 2002 Apr;95(4):211-8
pubmed: 11937647
Scand J Immunol. 1985 Mar;21(3):283-7
pubmed: 3922050
Rom J Morphol Embryol. 2019;60(4):1299-1303
pubmed: 32239108
Acta Haematol. 2020;143(4):322-334
pubmed: 32392555
Hum Pathol. 2007 Dec;38(12):1798-809
pubmed: 17714761
Clin Kidney J. 2014 Apr;7(2):97-106
pubmed: 25852856
Adv Ther. 2015 Oct;32(10):920-8
pubmed: 26498944
Adv Clin Chem. 2019;90:25-80
pubmed: 31122611
Saudi J Kidney Dis Transpl. 2018 Sep-Oct;29(5):1065-1072
pubmed: 30381502
N Engl J Med. 2007 Jun 7;356(23):2361-71
pubmed: 17554117
J Am Soc Nephrol. 2006 Dec;17(12):3458-71
pubmed: 17093068
Hum Mol Genet. 1995 Jun;4(6):1083-7
pubmed: 7655463
Int Urol Nephrol. 2009 Dec;41(4):941-5
pubmed: 19184513
Nephrol Dial Transplant. 2008 Mar;23(3):941-51
pubmed: 17951308
Blood. 2012 Feb 23;119(8):1844-7
pubmed: 21917755
Br Med Bull. 2013;107:41-56
pubmed: 23896486
Biosci Rep. 2019 Jan 15;39(1):
pubmed: 30567726
Ren Fail. 2012;34(10):1212-6
pubmed: 23009273
Arch Pathol Lab Med. 2010 Apr;134(4):545-51
pubmed: 20367306
Nephrol Dial Transplant. 2017 May 1;32(5):770-780
pubmed: 27540044
Blood. 2010 Nov 4;116(18):3426-30
pubmed: 20644111
N Engl J Med. 2002 Jun 6;346(23):1786-91
pubmed: 12050338