New Insights in Cytokines in Childhood Obesity: Changes in TWEAK and CD163 After a 2-Year Intervention Program in Prepubertal Children With Obesity.
CD163
TWEAK
childhood
obesity
prepubertal
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2022
2022
Historique:
received:
31
03
2022
accepted:
07
06
2022
entrez:
28
7
2022
pubmed:
29
7
2022
medline:
30
7
2022
Statut:
epublish
Résumé
Obesity is characterized by a low-grade inflammatory state in adipose tissue. Tumor Necrosis Factor Weak Inducer of Apoptosis (TWEAK) and Cluster of Differentiation 163 (CD163) are cytokines potentially involved in the pathogenesis of obesity. Little is known about them in children. The aim of this study was to observe serum levels of TWEAK and CD163 in prepubertal children with obesity compared to lean, and to evaluate its changes after a 2-year intervention program in children with obesity. Case-control study with a prospective follow-up of cases for 2 years in a referral pediatric endocrine outpatient centre. Seventy-three prepubertal children with obesity, and forty-seven age- and gender-matched lean controls were studied. Sixty-two cases finished the program. Anthropometric parameters, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), lipid profile, and concentrations of TWEAK and CD163 were determined. Children with obesity were re-evaluated after a 2-year intervention program consisting of diet and exercise. Weight loss was considered if z-score Body Mass Index (BMI) decreased at least 0.5 Standard Deviations (SD). We observed higher CD163 levels in children with obesity compared to controls. No significant differences were observed in TWEAK and CD163/TWEAK ratio at baseline. After the 2-year intervention program, TWEAK levels were higher and CD163/TWEAK ratio was lower in children with weight loss than those without weight loss. CD163 decreased in both groups. TWEAK and CD163 seem to have a role in the pathogenesis of obesity in prepubertal children.
Identifiants
pubmed: 35898446
doi: 10.3389/fendo.2022.909201
pmc: PMC9309174
doi:
Substances chimiques
Antigens, CD
0
Antigens, Differentiation, Myelomonocytic
0
CD163 antigen
0
Cytokine TWEAK
0
Cytokines
0
Receptors, Cell Surface
0
TNFSF12 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
909201Informations de copyright
Copyright © 2022 Escartín, Font, González-Clemente, Vendrell, Caixàs and Corripio.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Arch Dis Child. 2004 May;89(5):419-22
pubmed: 15102630
Gynecol Endocrinol. 2017 Mar;33(3):179-184
pubmed: 28102091
Eur J Endocrinol. 2020 Jan;182(1):G1-G32
pubmed: 31855556
Pediatrics. 2004 Aug;114(2 Suppl 4th Report):555-76
pubmed: 15286277
Drug News Perspect. 2006 Dec;19(10):589-95
pubmed: 17299600
BMJ. 2000 May 6;320(7244):1240-3
pubmed: 10797032
Front Immunol. 2013 Dec 30;4:488
pubmed: 24416031
Obesity (Silver Spring). 2013 Dec;21(12):2437-43
pubmed: 23512476
J Immunol. 2007 Jun 15;178(12):8183-94
pubmed: 17548657
Int J Pediatr Obes. 2006;1(1):33-41
pubmed: 17902213
Diabetes Care. 2004 Jan;27 Suppl 1:S5-S10
pubmed: 14693921
Int J Mol Sci. 2017 Aug 15;18(8):
pubmed: 28809783
Diabetologia. 1985 Jul;28(7):412-9
pubmed: 3899825
Immunity. 2022 Jan 11;55(1):31-55
pubmed: 35021057
Front Immunol. 2021 Jun 24;12:650768
pubmed: 34248937
Eur J Endocrinol. 2010 Dec;163(6):887-93
pubmed: 20870707
Cytokine. 2006 Feb 7;33(3):129-37
pubmed: 16503147
Arch Biochem Biophys. 2021 Sep 15;708:108951
pubmed: 34102165
Arch Dis Child. 1969 Jun;44(235):291-303
pubmed: 5785179
J Clin Endocrinol Metab. 2013 Aug;98(8):E1323-33
pubmed: 23783093
Eur J Clin Nutr. 1990 Jan;44(1):45-60
pubmed: 2354692
Med Clin (Barc). 2003 Nov 29;121(19):725-32
pubmed: 14678693
J Clin Endocrinol Metab. 2014 Mar;99(3):E474-8
pubmed: 24423308
Cardiovasc Diabetol. 2020 Jun 13;19(1):79
pubmed: 32534575
J Clin Endocrinol Metab. 2013 Aug;98(8):3482-90
pubmed: 23760626
Eur J Endocrinol. 2004 Aug;151(2):199-206
pubmed: 15296475
N Engl J Med. 2004 Jun 3;350(23):2362-74
pubmed: 15175438
Endocrinology. 2009 Dec;150(12):5373-83
pubmed: 19887572
Front Cardiovasc Med. 2021 Oct 25;8:768119
pubmed: 34760952
J Clin Endocrinol Metab. 2010 Jun;95(6):2983-92
pubmed: 20382683
Arch Dis Child. 1970 Feb;45(239):13-23
pubmed: 5440182
Pediatr Obes. 2015 Jun;10(3):226-33
pubmed: 25073966
Antioxid Redox Signal. 2013 Jun 10;18(17):2352-63
pubmed: 22900885
Lancet. 2004 Sep 11-17;364(9438):937-52
pubmed: 15364185
N Engl J Med. 2002 Mar 14;346(11):802-10
pubmed: 11893791
Eur Cytokine Netw. 2018 Sep 1;29(3):83-94
pubmed: 30547890