Effects of camphor and related compounds on slowly adapting mechanoreceptors in the rat sinus hair follicle.
Camphor
Rat vibrissal hair follicle
Single fibre recording
Slowly adapting mechanoreceptors
Somatosensory
TRP channels
Journal
IBRO neuroscience reports
ISSN: 2667-2421
Titre abrégé: IBRO Neurosci Rep
Pays: Netherlands
ID NLM: 101775148
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
19
04
2022
revised:
16
06
2022
accepted:
16
07
2022
entrez:
28
7
2022
pubmed:
29
7
2022
medline:
29
7
2022
Statut:
epublish
Résumé
Camphor is a popular compound for therapeutic and cosmetic use with a distinctive odour, and somatosensory warming and cooling properties. The mechanisms for its action remain unclear. The current study examined the effects of two enantiomers of camphor and related monoterpenoid compounds on mechanoreceptors. Extracellular recordings were made in an All compounds tested (0.5 - 2 mM bath concentrations) resulted in dose-dependent depression of spontaneous and mechanically evoked firing (dynamic and static phases). The mean latency of responses also increased. Both St I and St II were similarly affected, although (-)-camphor had a greater depressant effect on St II than on St I units. Differences were found across the different compounds for their effect on the dynamic and static phases. Thymol was found to have the greatest depressant effect on these phases. The broad spectrum TRP blocker ruthenium red did not reverse the depressant effects of camphor. The depressant effects of the compounds appeared similar to those obtained using the local anaesthetic lignocaine. The depressant effects of camphor and of lignocaine were partially reversed by the K The results question whether the depressant effects of camphor and related compounds act through TRP channels. Perhaps the use of more selective blockers may reveal the molecular mechanisms through which these compounds act.
Identifiants
pubmed: 35899231
doi: 10.1016/j.ibneur.2022.07.002
pii: S2667-2421(22)00047-1
pmc: PMC9310123
doi:
Types de publication
Journal Article
Langues
eng
Pagination
114-119Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors have no conflict of interest of any kind in relation to this paper.
Références
Brain Res. 1985 Feb 11;326(2):203-12
pubmed: 3871652
Biol Pharm Bull. 2014;37(12):1913-8
pubmed: 25451841
Commun Biol. 2021 Mar 5;4(1):293
pubmed: 33674682
Eur J Pharmacol. 2004 Dec 3;506(1):9-16
pubmed: 15588619
Chem Senses. 2013 Sep;38(7):563-75
pubmed: 23828908
Nature. 2002 Mar 7;416(6876):52-8
pubmed: 11882888
Neurosci Lett. 1996 Jul 26;213(1):1-4
pubmed: 8844698
Biochim Biophys Acta. 1979 Oct 18;587(3):424-32
pubmed: 45003
Psychon Bull Rev. 1994 Dec;1(4):476-90
pubmed: 24203555
Molecules. 2022 Apr 22;27(9):
pubmed: 35566046
Cell. 2003 Mar 21;112(6):819-29
pubmed: 12654248
J Neurosci. 2010 Sep 15;30(37):12219-29
pubmed: 20844118
Physiol Res. 2012;61(1):113-24
pubmed: 21574765
Acta Otolaryngol. 1983 Jul-Aug;96(1-2):157-61
pubmed: 6613544
Science. 1999 Jun 25;284(5423):2171-4
pubmed: 10381881
Life Sci. 1969 Mar 1;8(5):319-29
pubmed: 5781321
Biochem Biophys Res Commun. 2008 May 30;370(2):295-300
pubmed: 18371303
Neuroscience. 2005;133(3):763-73
pubmed: 15908129
J Physiol. 1997 Apr 1;500 ( Pt 1):29-37
pubmed: 9097930
Ann N Y Acad Sci. 2013 Mar;1279:13-21
pubmed: 23530998
Annu Rev Physiol. 2006;68:619-47
pubmed: 16460286
Molecules. 2013 May 10;18(5):5434-54
pubmed: 23666009
Neuroscience. 2009 Oct 20;163(3):933-41
pubmed: 19596050
J Neurosci. 2005 Sep 28;25(39):8924-37
pubmed: 16192383
Nat Prod Commun. 2010 Dec;5(12):1999-2006
pubmed: 21299140
Hum Neurobiol. 1984;3(1):3-14
pubmed: 6330008
Q J Exp Physiol Cogn Med Sci. 1972 Oct;57(4):417-45
pubmed: 4484588
South Med J. 2000 Jun;93(6):596-8
pubmed: 10881777
J Physiol. 1969 Feb;200(3):763-96
pubmed: 4974746
Neuroreport. 2001 Feb 12;12(2):341-7
pubmed: 11209947
Biochem Pharmacol. 2001 Apr 1;61(7):787-93
pubmed: 11274963
J Physiol. 1973 Dec;235(2):287-315
pubmed: 4763992
J Invest Dermatol. 1990 May;94(5):662-6
pubmed: 2324522
Exp Neurol. 1965 Dec;13(4):364-85
pubmed: 5847283
Science. 2005 Mar 4;307(5714):1468-72
pubmed: 15746429
J Peripher Nerv Syst. 2009 Dec;14(4):300-9
pubmed: 20021572
J Physiol. 1969 Feb;200(2):403-30
pubmed: 4974402
J Neurosci. 2008 Oct 1;28(40):9929-38
pubmed: 18829951
J Emerg Med. 2004 Jul;27(1):49-54
pubmed: 15219304
Nature. 2007 Feb 22;445(7130):858-65
pubmed: 17314972
Neuroscience. 2007 Aug 24;148(2):489-500
pubmed: 17683869
Eur J Neurosci. 2006 Aug;24(3):691-8
pubmed: 16848799
Int J Mol Sci. 2020 Sep 25;21(19):
pubmed: 32992914
Skin Pharmacol Physiol. 2020;33(5):253-260
pubmed: 33053558
Mol Cell Neurosci. 2006 Aug;32(4):335-43
pubmed: 16829128
Mol Pain. 2022 Jan-Dec;18:17448069221076606
pubmed: 35189758
Food Chem Toxicol. 2008 Nov;46 Suppl 11:S88-90
pubmed: 18640177
Pharmaceuticals (Basel). 2019 Feb 02;12(1):
pubmed: 30717379