Environmental Chemical Exposures and Mitochondrial Dysfunction: a Review of Recent Literature.
Environmental chemicals
Heteroplasmy
Mitochondrial dysfunction
Oxidative stress
mtDNA
Journal
Current environmental health reports
ISSN: 2196-5412
Titre abrégé: Curr Environ Health Rep
Pays: Switzerland
ID NLM: 101629387
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
accepted:
20
07
2022
pubmed:
29
7
2022
medline:
15
12
2022
entrez:
28
7
2022
Statut:
ppublish
Résumé
Mitochondria play various roles that are important for cell function and survival; therefore, significant mitochondrial dysfunction may have chronic consequences that extend beyond the cell. Mitochondria are already susceptible to damage, which may be exacerbated by environmental exposures. Therefore, the aim of this review is to summarize the recent literature (2012-2022) looking at the effects of six ubiquitous classes of compounds on mitochondrial dysfunction in human populations. The literature suggests that there are a number of biomarkers that are commonly used to identify mitochondrial dysfunction, each with certain advantages and limitations. Classes of environmental toxicants such as polycyclic aromatic hydrocarbons, air pollutants, heavy metals, endocrine-disrupting compounds, pesticides, and nanomaterials can damage the mitochondria in varied ways, with changes in mtDNA copy number and measures of oxidative damage the most commonly measured in human populations. Other significant biomarkers include changes in mitochondrial membrane potential, calcium levels, and ATP levels. This review identifies the biomarkers that are commonly used to characterize mitochondrial dysfunction but suggests that emerging mitochondrial biomarkers, such as cell-free mitochondria and blood cardiolipin levels, may provide greater insight into the impacts of exposures on mitochondrial function. This review identifies that the mtDNA copy number and measures of oxidative damage are commonly used to characterize mitochondrial dysfunction, but suggests using novel approaches in addition to well-characterized ones to create standardized protocols. We identified a dearth of studies on mitochondrial dysfunction in human populations exposed to metals, endocrine-disrupting chemicals, pesticides, and nanoparticles as a gap in knowledge that needs attention.
Identifiants
pubmed: 35902457
doi: 10.1007/s40572-022-00371-7
pii: 10.1007/s40572-022-00371-7
pmc: PMC9729331
mid: NIHMS1851547
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
631-649Subventions
Organisme : NIEHS NIH HHS
ID : R00 ES030749
Pays : United States
Informations de copyright
© 2022. The Author(s).
Références
Mitochondrion. 2022 Jan;62:102-110
pubmed: 34785263
Pediatr Nephrol. 2021 Jan;36(1):9-17
pubmed: 31925537
Trends Endocrinol Metab. 2017 Apr;28(4):250-260
pubmed: 27986466
Environ Int. 2017 Jan;98:198-203
pubmed: 27843010
Crit Care. 2012 Aug 13;16(4):R151
pubmed: 22889177
Int J Mol Med. 2019 Jul;44(1):3-15
pubmed: 31115493
Part Fibre Toxicol. 2013 May 08;10:18
pubmed: 23656717
Circ Res. 2016 Jun 10;118(12):1960-91
pubmed: 27126807
Appl Microbiol Biotechnol. 2014 Jun;98(11):5153-60
pubmed: 24652061
Chemosphere. 2020 Dec;261:127628
pubmed: 32731016
J Am Heart Assoc. 2018 Sep 18;7(18):e010009
pubmed: 30371200
PLoS Comput Biol. 2012;8(10):e1002737
pubmed: 23133345
Gene. 2002 Mar 6;286(1):127-34
pubmed: 11943468
Neural Regen Res. 2013 Jul 25;8(21):2003-14
pubmed: 25206509
Free Radic Biol Med. 2014 Nov;76:25-33
pubmed: 25101517
Exp Mol Med. 2017 Feb 3;49(2):e291
pubmed: 28154371
Iran J Basic Med Sci. 2019 Nov;22(11):1353-1358
pubmed: 32128102
IUBMB Life. 2006 Jul;58(7):403-8
pubmed: 16801215
Environ Health Perspect. 2016 Jul;124(7):943-50
pubmed: 26672058
Sci Total Environ. 2022 Mar 20;813:151899
pubmed: 34838543
Int J Mol Sci. 2019 Mar 06;20(5):
pubmed: 30845725
Toxicol Res (Camb). 2019 Oct 22;8(6):994-1001
pubmed: 32922740
World J Gastroenterol. 2014 Oct 21;20(39):14205-18
pubmed: 25339807
Chemosphere. 2020 Mar;243:125335
pubmed: 31765894
FASEB J. 2010 Apr;24(4):1249-60
pubmed: 19966135
Toxicol In Vitro. 2018 Sep;51:11-22
pubmed: 29715505
Subcell Biochem. 2010;50:211-22
pubmed: 20012584
Curr Mol Med. 2022;22(1):37-49
pubmed: 33602082
Environ Int. 2018 Mar;112:49-58
pubmed: 29248865
Biomaterials. 2016 Jul;93:83-94
pubmed: 27085073
Front Cell Dev Biol. 2020 Nov 30;8:604377
pubmed: 33330504
Methods Mol Biol. 2016;1473:17-22
pubmed: 27518619
Nat Rev Genet. 2015 Sep;16(9):530-42
pubmed: 26281784
J Med Chem. 2016 Dec 8;59(23):10411-10434
pubmed: 27560192
FEBS Lett. 2019 Jul;593(13):1528-1541
pubmed: 31058316
Dev Disabil Res Rev. 2010;16(2):189-99
pubmed: 20818734
Mitochondrion. 2019 May;46:22-29
pubmed: 30980914
Biochem Biophys Res Commun. 2002 May 31;294(1):116-9
pubmed: 12054749
Carcinogenesis. 2012 Feb;33(2):240-52
pubmed: 22166497
Environ Mol Mutagen. 2008 Jul;49(6):453-7
pubmed: 18481315
J Intern Med. 2021 Jan;289(1):84-96
pubmed: 32634278
Nature. 1980 Sep 18;287(5779):244-5
pubmed: 7432460
Nature. 2016 Jul 28;535(7613):498-500
pubmed: 27383787
Toxicol In Vitro. 2019 Dec;61:104639
pubmed: 31491480
Environ Int. 2020 Oct;143:105920
pubmed: 32653801
Mitochondrion. 2020 Jul;53:214-223
pubmed: 32544465
Int J Geriatr Psychiatry. 2018 Oct;33(10):1319-1326
pubmed: 29984425
Environ Int. 2019 Aug;129:470-477
pubmed: 31158593
Mitochondrion. 2021 Jul;59:225-245
pubmed: 33839318
Antioxid Redox Signal. 2015 Aug 20;23(6):578-95
pubmed: 25826672
ScientificWorldJournal. 2012;2012:136063
pubmed: 22619586
J Biomed Sci. 2000 Jan-Feb;7(1):2-15
pubmed: 10644884
Chem Biol Interact. 2010 Nov 5;188(2):334-9
pubmed: 20637748
Environ Pollut. 2020 Oct;265(Pt B):114594
pubmed: 32504974
J Toxicol Clin Toxicol. 2000;38(4):407-13
pubmed: 10930057
Environ Toxicol Pharmacol. 2008 Jul;26(1):1-5
pubmed: 21783880
Environ Sci Pollut Res Int. 2020 Jul;27(20):24799-24814
pubmed: 32358751
Environ Pollut. 2020 May;260:114026
pubmed: 32006885
Am J Epidemiol. 2015 Apr 15;181(8):575-83
pubmed: 25770981
Environ Res. 2020 Mar;182:109080
pubmed: 31901629
Redox Biol. 2017 Oct;13:407-417
pubmed: 28683400
J Physiol. 2017 Jun 15;595(12):3753-3763
pubmed: 28105746
BMC Med. 2012 Jun 19;10:61
pubmed: 22713677
Circ Res. 2020 Jan 17;126(2):280-293
pubmed: 31944918
Nucleic Acids Res. 2009 Feb;37(3):749-61
pubmed: 19074198
Ecotoxicol Environ Saf. 2019 Oct 30;182:109384
pubmed: 31272023
Environ Pollut. 2017 Jan;220(Pt A):680-687
pubmed: 27751638
Reprod Toxicol. 2019 Oct;89:83-92
pubmed: 31315019
Biochemistry (Mosc). 2017 Oct;82(10):1140-1146
pubmed: 29037134
Sci Total Environ. 2019 Feb 15;651(Pt 1):885-894
pubmed: 30257229
PLoS One. 2013 May 03;8(5):e63208
pubmed: 23658810
Carcinogenesis. 2017 Sep 1;38(9):893-899
pubmed: 28911003
Science. 1980 Jul 11;209(4453):297-9
pubmed: 6770466
IUBMB Life. 2020 Sep;72(9):1879-1890
pubmed: 32656943
Part Fibre Toxicol. 2013 Apr 29;10:17
pubmed: 23628000
Sci Rep. 2017 Apr 11;7:46339
pubmed: 28397872
Circ Res. 2018 May 11;122(10):1460-1478
pubmed: 29748369
Toxicol In Vitro. 2011 Apr;25(3):664-70
pubmed: 21232593
Toxicol Res (Camb). 2017 Mar 17;6(3):353-360
pubmed: 30090504
Cardiovasc Diabetol. 2016 Mar 31;15:53
pubmed: 27036979
Environ Res. 2018 May;163:10-15
pubmed: 29421168
Environ Health. 2017 Aug 18;16(1):87
pubmed: 28821289
Part Fibre Toxicol. 2020 Jun 1;17(1):18
pubmed: 32487172
Environ Int. 2018 Oct;119:47-53
pubmed: 29933237
Environ Health Perspect. 2012 Feb;120(2):210-5
pubmed: 22005026
Toxicology. 2015 Mar 2;329:21-31
pubmed: 25572651
Int J Toxicol. 2020 Sep/Oct;39(5):465-476
pubmed: 32588678
Toxicology. 2017 Nov 1;391:18-33
pubmed: 28838641
Biomedicines. 2020 Dec 10;8(12):
pubmed: 33321831
FEBS Lett. 2018 Mar;592(5):728-742
pubmed: 29281123
Nat Rev Mol Cell Biol. 2018 Nov;19(11):713-730
pubmed: 30143745
Cells. 2019 Jul 16;8(7):
pubmed: 31315173
Environ Health Perspect. 2017 Jan;125(1):104-110
pubmed: 27448387
Environ Pollut. 2019 Sep;252(Pt A):330-335
pubmed: 31158661
Mitochondrion. 2021 Jul;59:267-275
pubmed: 34102325
Cell. 2020 Apr 2;181(1):168-188
pubmed: 32220313
Sci Total Environ. 2020 Feb 1;702:134994
pubmed: 31715400
Environ Res. 2020 Sep;188:109816
pubmed: 32593898
Epigenetics. 2015;10(6):536-44
pubmed: 25996590
Physiol Rev. 2014 Jul;94(3):909-50
pubmed: 24987008
Toxicol Sci. 2015 May;145(1):149-56
pubmed: 25677926
Metallomics. 2017 Jul 19;9(7):969-980
pubmed: 28644490
Cell Calcium. 2018 Jan;69:62-72
pubmed: 28515000
Front Cell Dev Biol. 2017 Sep 29;5:90
pubmed: 29034233
J Am Soc Nephrol. 2016 Aug;27(8):2467-73
pubmed: 26794963
Front Microbiol. 2020 Nov 05;11:562813
pubmed: 33224110
Am J Physiol Endocrinol Metab. 2021 May 1;320(5):E859-E863
pubmed: 33719587
Chemosphere. 2021 Jul;274:129845
pubmed: 33979940
FEBS Lett. 2018 Mar;592(5):692-702
pubmed: 29292494
Toxicology. 2017 Nov 1;391:2-4
pubmed: 28627407
Genetics. 2020 Feb;214(2):381-395
pubmed: 31852725
Chemosphere. 2016 Nov;163:27-34
pubmed: 27521637
Endocr Rev. 2012 Jun;33(3):378-455
pubmed: 22419778
Cell Metab. 2016 Feb 9;23(2):379-85
pubmed: 26712463
Sci Rep. 2014 Jan 27;4:3887
pubmed: 24463429
Anal Biochem. 2018 Jul 1;552:50-59
pubmed: 28711444
Toxicol Lett. 2010 Sep 15;198(1):49-55
pubmed: 20417263
PLoS One. 2013 May 31;8(5):e64413
pubmed: 23741329
Exp Mol Med. 2019 Dec 19;51(12):1-13
pubmed: 31857574
F1000Res. 2017 Feb 20;6:169
pubmed: 28299196
J Toxicol Environ Health A. 2018;81(15):705-717
pubmed: 29913117
Biochem J. 2011 Apr 15;435(2):297-312
pubmed: 21726199
Toxicol Sci. 2020 Nov 1;178(1):16-25
pubmed: 32777053
Dev Biol. 2009 Jun 1;330(1):123-30
pubmed: 19328778
Sci Rep. 2017 Apr 04;7:45465
pubmed: 28374803
Biochem J. 2000 Jun 1;348 Pt 2:425-32
pubmed: 10816438
Mol Psychiatry. 2021 May;26(5):1561-1577
pubmed: 32963337
J Appl Toxicol. 2017 Aug;37(8):1004-1016
pubmed: 28261831
Toxicol Lett. 2014 Jul 15;228(2):85-92
pubmed: 24768697
J Biol Chem. 2003 Mar 7;278(10):8516-25
pubmed: 12496265
Am J Kidney Dis. 2016 Oct;68(4):658-659
pubmed: 27312460
Neurotoxicology. 2019 Dec;75:174-185
pubmed: 31550440
Cancer Epidemiol Biomarkers Prev. 2013 Oct;22(10):1722-9
pubmed: 23885040
Sci Rep. 2016 Apr 11;6:23992
pubmed: 27063412
Arch Toxicol. 2015 Feb;89(2):147-53
pubmed: 25559775
Arch Biochem Biophys. 2002 Sep 15;405(2):252-64
pubmed: 12220540
Environ Mol Mutagen. 2010 Jun;51(5):462-75
pubmed: 20175113
Cell. 2015 Oct 22;163(3):560-9
pubmed: 26496603
Biochim Biophys Acta. 2009 Nov;1787(11):1395-401
pubmed: 19576166
Environ Int. 2014 Dec;73:323-33
pubmed: 25216151
Mitochondrion. 2021 Sep;60:1-11
pubmed: 34157430
Exp Mol Pathol. 2020 Jun;114:104412
pubmed: 32113905
Aging Cell. 2017 Oct;16(5):943-955
pubmed: 28758328
Free Radic Biol Med. 2004 Jun 1;36(11):1434-43
pubmed: 15135180
J Gerontol A Biol Sci Med Sci. 2012 Oct;67(10):1022-35
pubmed: 22459622
EBioMedicine. 2021 Mar;65:103244
pubmed: 33647769
Biol Trace Elem Res. 2018 Aug;184(2):422-435
pubmed: 29189995
PLoS One. 2017 Jun 22;12(6):e0179861
pubmed: 28640859
Carcinogenesis. 2021 Nov 12;42(11):1326-1336
pubmed: 34606590
Mol Psychiatry. 2012 Apr;17(4):389-401
pubmed: 22143005
J Endocrinol. 2018 Nov 1;239(2):R27-R45
pubmed: 30072426
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Apr;27(2):120-39
pubmed: 19412858
PLoS One. 2020 Jan 31;15(1):e0228166
pubmed: 32004343
Trends Endocrinol Metab. 2016 Feb;27(2):105-117
pubmed: 26754340
FASEB J. 2020 Mar;34(3):3616-3630
pubmed: 31957088
Biochim Biophys Acta Mol Basis Dis. 2020 Jun 1;1866(6):165744
pubmed: 32105822
Toxicol Sci. 2013 Jul;134(1):1-17
pubmed: 23629515
Nat Rev Genet. 2005 May;6(5):389-402
pubmed: 15861210
Part Fibre Toxicol. 2019 Apr 11;16(1):18
pubmed: 30975174
Curr Genomics. 2016 Jun;17(3):215-9
pubmed: 27252588
Toxicology. 2017 Nov 1;391:84-89
pubmed: 28750850
J Biol Chem. 2017 Jul 14;292(28):11727-11739
pubmed: 28546431
Environ Health Perspect. 2016 May;124(5):659-65
pubmed: 26317635
Redox Biol. 2015 Dec;6:472-485
pubmed: 26432659
Life Sci. 2018 Jan 1;192:26-32
pubmed: 29155300
Int J Mol Sci. 2019 Feb 02;20(3):
pubmed: 30717385
Environ Health. 2018 Mar 27;17(1):29
pubmed: 29587765
J Physiol. 2000 Nov 15;529 Pt 1:57-68
pubmed: 11080251
Circulation. 2016 Jan 26;133(4):378-87
pubmed: 26660284
Int J Endocrinol. 2020 Jul 15;2020:3650937
pubmed: 32733553
Toxicol Sci. 2014 Nov;142(1):6-20
pubmed: 25092649
Biomed Res Int. 2014;2014:292017
pubmed: 24818137
Environ Health Perspect. 2021 Nov;129(11):117007
pubmed: 34797165
Life (Basel). 2021 Sep 10;11(9):
pubmed: 34575097
Toxicol Sci. 2015 Jul;146(1):31-42
pubmed: 25809595
Nutr Neurosci. 2022 May;25(5):990-1000
pubmed: 33023416
Exp Gerontol. 2019 Jan;115:96-103
pubmed: 30508565
JAMA Cardiol. 2017 Nov 1;2(11):1247-1255
pubmed: 29049454
Arh Hig Rada Toksikol. 2017 Dec 20;68(4):261-275
pubmed: 29337682
J Hazard Mater. 2021 Jul 15;414:125437
pubmed: 34030398
Free Radic Biol Med. 2016 Nov;100:123-137
pubmed: 27091692
Methods Enzymol. 2009;456:381-93
pubmed: 19348900
Chemosphere. 2020 May;246:125773
pubmed: 31911328
Sci Rep. 2021 Sep 13;11(1):18137
pubmed: 34518572
Environ Int. 2019 May;126:484-493
pubmed: 30849576
Redox Rep. 2009;14(3):102-8
pubmed: 19490751
Int J Biochem Cell Biol. 2005 Apr;37(4):822-34
pubmed: 15694841
Biol Trace Elem Res. 2014 Dec;162(1-3):270-7
pubmed: 25161091
Environ Int. 2019 Apr;125:437-444
pubmed: 30753999
Sci Rep. 2019 Feb 14;9(1):2002
pubmed: 30765730
Epidemiology. 2017 Nov;28(6):763-770
pubmed: 28953603
J Appl Toxicol. 2016 Feb;36(2):179-88
pubmed: 26510484
Trends Neurosci. 2000 Jul;23(7):298-304
pubmed: 10856939
Environ Health. 2010 Aug 09;9:48
pubmed: 20696069
Environ Health. 2016 Jan 20;15:10
pubmed: 26792633
Int J Mol Sci. 2021 May 03;22(9):
pubmed: 34063708
Adv Exp Med Biol. 2017;982:577-594
pubmed: 28551808
Nanoscale. 2017 Jun 8;9(22):7595-7601
pubmed: 28537609
Chemosphere. 2021 Jan;263:128019
pubmed: 33297043
Can J Diabetes. 2019 Feb;43(1):67-75.e1
pubmed: 30146472
Circ Res. 2020 Mar 27;126(7):926-941
pubmed: 32213135
FEBS Lett. 2021 Apr;595(8):976-1002
pubmed: 33314045