The Cerebellum and Disorders of Emotion.
Cerebellum
Disorder
Emotion
Homeostasis
Predictive coding
Journal
Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
28
7
2022
pubmed:
29
7
2022
medline:
2
8
2022
Statut:
ppublish
Résumé
Neuropsychological and experimental brain research have provided independent lines of evidence in support of cerebellar involvement in disorders of emotion. Medial cerebellar structures and their connections to the limbic system are involved in visceral aspects and the generation of emotions, whereas the posterolateral cerebello-thalamo-cortical loops are implicated in emotion regulation and subjective sense of control. Disturbances within these cerebellar-centred circuits are proposed to underlie homeostatic dysregulation and suboptimal predictive coding that provide a transdiagnostic mechanism by which the cerebellum may contribute to the vulnerability and persistence of mental disorders.
Identifiants
pubmed: 35902477
doi: 10.1007/978-3-030-99550-8_17
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
273-283Informations de copyright
© 2022. The Author(s), under exclusive license to Springer Nature Switzerland AG.
Références
Adamaszek M, D’Agata F, Ferrucci R, Habas C, Keulen S, Kirkby KC, Leggio M, Mariën P, Molinari M, Moulton E, Orsi L, Van Overwalle F, Papadelis C, Priori A, Sacchetti B, Schutter DJ, Styliadis C, Verhoeven J (2017) Consensus paper: cerebellum and emotion. Cerebellum 16:552–576
pubmed: 27485952
American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders. 4th edn DSM-V. American Psychiatric Association, Washington, DC
American Psychological Association (2021) https://dictionary.apa.org/mental-disorder
Anticevic A, Hu S, Zhang S, Savic A, Billingslea E, Wasylink S, Repovs G, Cole MW, Bednarski S, Krystal JH, Bloch MH, Li CS, Pittenger C (2014) Global resting-state functional magnetic resonance imaging analysis identifies frontal cortex, striatal, and cerebellar dysconnectivity in obsessive-compulsive disorder. Biol Psychiatry 75:595–605
pubmed: 24314349
doi: 10.1016/j.biopsych.2013.10.021
Bai L, Niu X, Liu Z, Chen Z, Wang X, Sun C, Wang Z, Wang S, Cao J, Gan S, Fan G, Huang W, Xu H, Chen S, Tian J, Lao L, Zhang M (2018) The role of insula-cerebellum connection underlying aversive regulation with acupuncture. Mol Pain 14. https://doi.org/10.1177/1744806918783457
Balsters JH, Cussans E, Diedrichsen J, Phillips KA, Preuss TM, Rilling JK, Ramnani N (2010) Evolution of the cerebellar cortex: the selective expansion of prefrontal-projecting cerebellar lobules. Neuroimage 49:2045–2052
pubmed: 19857577
doi: 10.1016/j.neuroimage.2009.10.045
Berle D, Phillips ES (2006) Disgust and obsessive-compulsive disorder: an update. Psychiatry 69:228–238
pubmed: 17040174
doi: 10.1521/psyc.2006.69.3.228
Bertsch K, Grothe M, Prehn K, Vohs K, Berger C, Hauenstein K, Keiper P, Domes G, Teipel S, Herpertz SC (2013) Brain volumes differ between diagnostic groups of violent criminal offenders. Eur Arch Psychiatry Clin Neurosci 263:593–606
pubmed: 23381548
doi: 10.1007/s00406-013-0391-6
Caulfield MD, Zhu DC, McAuley JD, Servatius RJ (2016) Individual differences in resting-state functional connectivity with the executive network: support for a cerebellar role in anxiety vulnerability. Brain Struct Funct 221:3081–3093
pubmed: 26231515
doi: 10.1007/s00429-015-1088-6
Cerminara NL, Lang EJ, Sillitoe RV, Apps R (2015) Redefining the cerebellar cortex as an assembly of non-uniform Purkinje cell microcircuits. Nat Rev Neurosci 16:79–93
pubmed: 25601779
pmcid: 4476393
doi: 10.1038/nrn3886
Cooper IS, Amin I, Riklan M, Waltz JM, Poon TP (1976) Chronic cerebellar stimulation in epilepsy. Clinical and anatomical studies. Arch Neurol 33:559–570
pubmed: 821458
doi: 10.1001/archneur.1976.00500080037006
Dalwani M, Sakai JT, Mikulich-Gilbertson SK, Tanabe J, Raymond K, McWilliams SK, Thompson LL, Banich MT, Crowley TJ (2011) Reduced cortical gray matter volume in male adolescents with substance and conduct problems. Drug Alcohol Depend 118:295–305
pubmed: 21592680
pmcid: 3170449
doi: 10.1016/j.drugalcdep.2011.04.006
De Brito SA, Mechelli A, Wilke M, Laurens KR, Jones AP, Barker GJ, Hodgins S, Viding E (2009) Size matters: increased grey matter in boys with conduct problems and callous-unemotional traits. Brain 132:843–852
pubmed: 19293245
doi: 10.1093/brain/awp011
Doyle JC, Alderson DL, Li L, Low S, Roughan M, Shalunov S, Tanaka R, Willinger W (2005) The “robust yet fragile” nature of the Internet. Proc Natl Acad Sci U S A 102:14497–14502
pubmed: 16204384
pmcid: 1240072
doi: 10.1073/pnas.0501426102
Eng GK, Sim K, Chen SH (2015) Meta-analytic investigations of structural grey matter, executive domain-related functional activations, and white matter diffusivity in obsessive compulsive disorder: an integrative review. Neurosci Biobehav Rev 52:233–257
pubmed: 25766413
doi: 10.1016/j.neubiorev.2015.03.002
Frankl V (2006) Man’s search for meaning. Beacon, Boston, MA
Friston K (2010) The free-energy principle: a unified brain theory? Nat Rev Neurosci 11:127–138
pubmed: 20068583
doi: 10.1038/nrn2787
Gong J, Wang J, Qiu S, Chen P, Luo Z, Wang J, Huang L, Wang Y (2020) Common and distinct patterns of intrinsic brain activity alterations in major depression and bipolar disorder: voxel-based meta-analysis. Transl Psychiatry 10:353
pubmed: 33077728
pmcid: 7573621
doi: 10.1038/s41398-020-01036-5
Guell X, Gabrieli JDE, Schmahmann JD (2018) Embodied cognition and the cerebellum: perspectives from the dysmetria of thought and the universal cerebellar transform theories. Cortex 100:140–148
pubmed: 28779872
doi: 10.1016/j.cortex.2017.07.005
Habas C (2018) Research note: a resting-state, cerebello-amygdaloid intrinsically connected network. Cerebellum Ataxias 5:4
pubmed: 29468083
pmcid: 5813397
doi: 10.1186/s40673-018-0083-0
Habas C, Kamdar N, Nguyen D, Prater K, Beckmann CF, Menon V, Greicius MD (2009) Distinct cerebellar contributions to intrinsic connectivity networks. J Neurosci 29:8586–8594
pubmed: 19571149
pmcid: 2742620
doi: 10.1523/JNEUROSCI.1868-09.2009
Heath RG (1977) Modulation of emotion with a brain pacemaker. Treatment for intractable psychiatric illness. J Nerv Ment Dis 165:300–317
pubmed: 303280
doi: 10.1097/00005053-197711000-00002
Heath RG, Llewellyn RC, Rouchell AM (1980) The cerebellar pacemaker for intractable behavioral disorders and epilepsy: follow-up report. Biol Psychiatry 15:243–256
pubmed: 7417614
Huebner T, Vloet TD, Marx I, Konrad K, Fink GR, Herpertz SC, Herpertz-Dahlmann B (2008) Morphometric brain abnormalities in boys with conduct disorder. J Am Acad Child Adolesc Psychiatry 47:540–547
pubmed: 18356764
doi: 10.1097/CHI.0b013e3181676545
Ito M (2008) Control of mental activities by internal models in the cerebellum. Nat Rev Neurosci 9:304–313
pubmed: 18319727
doi: 10.1038/nrn2332
Jackman SL, Chen CH, Offermann HL, Drew IR, Harrison BM, Bowman AM, Flick KM, Flaquer I, Regehr WG (2020) Cerebellar Purkinje cell activity modulates aggressive behavior. Elife 9:e53229
pubmed: 32343225
pmcid: 7202893
doi: 10.7554/eLife.53229
Kalisch R, Müller MB, Tüscher O (2015) A conceptual framework for the neurobiological study of resilience. Behav Brain Sci 38:e92
pubmed: 25158686
doi: 10.1017/S0140525X1400082X
Kelly DR (2011) Yuck!: the nature and moral significance of disgust (life and mind: philosophical issues in biology and psychology). MIT Press, Cambridge, MA
Klaus J, Schutter DJ (2021) Functional topography of anger and aggression in the human cerebellum. Neuroimage 226:117582
pubmed: 33221449
doi: 10.1016/j.neuroimage.2020.117582
Kolesar TA, Bilevicius E, Wilson AD, Kornelsen J (2019) Systematic review and meta-analyses of neural structural and functional differences in generalized anxiety disorder and healthy controls using magnetic resonance imaging. Neuroimage Clin 24:102016
pubmed: 31835287
pmcid: 6879983
doi: 10.1016/j.nicl.2019.102016
Kruithof E, Klaus J, Schutter DJ (in press) The cerebellum in aggression: extending the cortico-limbic dual-route model of motivation and emotion. Motivation Science
LeDoux J, Daw ND (2018) Surviving threats: neural circuit and computational implications of a new taxonomy of defensive behaviour. Nat Rev Neurosci 19:269–282
pubmed: 29593300
doi: 10.1038/nrn.2018.22
Ludvik D, Boschen MJ, Neumann DL (2015) Effective behavioural strategies for reducing disgust in contamination-related OCD: a review. Clin Psychol Rev 42:116–129
pubmed: 26190372
doi: 10.1016/j.cpr.2015.07.001
McEwen BS (1998) Stress, adaptation, and disease. Allostasis and allostatic load. Ann N Y Acad Sci 840:33–44
pubmed: 9629234
doi: 10.1111/j.1749-6632.1998.tb09546.x
Moberget T, Ivry RB (2016) Cerebellar contributions to motor control and language comprehension: searching for common computational principles. Ann N Y Acad Sci 1369:154–171
pubmed: 27206249
pmcid: 5260470
doi: 10.1111/nyas.13094
Nesse RM (1990) Evolutionary explanations of emotions. Hum Nat 1:261–289
pubmed: 24222085
doi: 10.1007/BF02733986
Nesse RM (1999) Proximate and evolutionary studies of anxiety, stress and depression: synergy at the interface. Neurosci Biobehav Rev 23:895–903
pubmed: 10580304
doi: 10.1016/S0149-7634(99)00023-8
Nesse RM (2000) Is depression an adaptation? Arch Gen Psychiatry 57:14–20
pubmed: 10632228
doi: 10.1001/archpsyc.57.1.14
Nesse RM (2001) The smoke detector principle. Natural selection and the regulation of defensive responses. Ann N Y Acad Sci 935:75–85
pubmed: 11411177
doi: 10.1111/j.1749-6632.2001.tb03472.x
Panksepp J (2006) Emotional endophenotypes in evolutionary psychiatry. Prog Neuropsychopharmacol Biol Psychiatry 30:774–784
pubmed: 16554114
doi: 10.1016/j.pnpbp.2006.01.004
Puri BK, Counsell SJ, Saeed N, Bustos MG, Treasaden IH, Bydder GM (2008) Regional grey matter volumetric changes in forensic schizophrenia patients: an MRI study comparing the brain structure of patients who have seriously and violently offended with that of patients who have not. BMC Psychiatry 8:1–6
doi: 10.1186/1471-244X-8-S1-S1
Rasgon A, Lee WH, Leibu E, Laird A, Glahn D, Goodman W, Frangou S (2017) Neural correlates of affective and non-affective cognition in obsessive compulsive disorder: a meta-analysis of functional imaging studies. Eur Psychiatry 46:25–32
pubmed: 28992533
doi: 10.1016/j.eurpsy.2017.08.001
Reis DJ, Doba N, Nathan MA (1973) Predatory attack, grooming, and consummatory behaviors evoked by electrical stimulation of cat cerebellar nuclei. Science 182:845–847
pubmed: 4795751
doi: 10.1126/science.182.4114.845
Rogers JC, De Brito SA (2016) Cortical and subcortical gray matter volume in youths with conduct problems: a meta-analysis. JAMA Psychiat 73:64–72
doi: 10.1001/jamapsychiatry.2015.2423
Schmahmann JD (1991) An emerging concept. The cerebellar contribution to higher function. Arch Neurol 48:1178–1187
pubmed: 1953406
doi: 10.1001/archneur.1991.00530230086029
Schmahmann JD (2010) The role of the cerebellum in cognition and emotion: personal reflections since 1982 on the dysmetria of thought hypothesis, and its historical evolution from theory to therapy. Neuropsychol Rev 20:236–260
pubmed: 20821056
doi: 10.1007/s11065-010-9142-x
Schmahmann JD, Sherman JC (1998) The cerebellar cognitive affective syndrome. Brain 121:561–579
pubmed: 9577385
doi: 10.1093/brain/121.4.561
Schmahmann JD, Weilburg JB, Sherman JC (2007) The neuropsychiatry of the cerebellum - insights from the clinic. Cerebellum 6(3):254–267
pubmed: 17786822
doi: 10.1080/14734220701490995
Schutter DJ (2013) Human cerebellum in motivation and emotion. In: Manto M et al (eds) Handbook of the cerebellum and cerebellar disorders. Springer, New York, pp 1771–1782
doi: 10.1007/978-94-007-1333-8_79
Schutter DJ (2016) A cerebellar framework for predictive coding and homeostatic regulation in depressive disorder. Cerebellum 15:30–33
pubmed: 26249226
doi: 10.1007/s12311-015-0708-2
Schutter DJ (2020) The cerebellum in emotion and psychopathology. Taylor & Francis, London
doi: 10.4324/9781315145082
Schutter DJ, van Honk J (2005) The cerebellum on the rise in human emotion. Cerebellum 4:290–294
pubmed: 16321885
doi: 10.1080/14734220500348584
Schutter DJ, van Honk J (2009) The cerebellum in emotion regulation: a repetitive transcranial magnetic stimulation study. Cerebellum 8:28–34
pubmed: 18855096
doi: 10.1007/s12311-008-0056-6
Schutter DJ, Wischnewski M, Bekkering H (2015) Stability through variability: homeostatic plasticity and psychological resilience. Behav Brain Sci 38:e118
pubmed: 26785748
doi: 10.1017/S0140525X14001678
Schutter DJ, Meuwese R, Bos MGN, Crone EA, Peper JS (2017) Exploring the role of testosterone in the cerebellum link to neuroticism: from adolescence to early adulthood. Psychoneuroendocrinology 78:203–212
pubmed: 28214680
doi: 10.1016/j.psyneuen.2017.01.009
Sereno MI, Diedrichsen J, Tachrount M, Testa-Silva G, d’Arceuil H, De Zeeuw C (2020) The human cerebellum has almost 80% of the surface area of the neocortex. Proc Natl Acad Sci U S A 117:19538–19543
pubmed: 32723827
pmcid: 7431020
doi: 10.1073/pnas.2002896117
Shapira NA, Liu Y, He AG, Bradley MM, Lessig MC, James GA, Stein DJ, Lang PJ, Goodman WK (2003) Brain activation by disgust-inducing pictures in obsessive-compulsive disorder. Biol Psychiatry 54:751–756
pubmed: 14512216
doi: 10.1016/S0006-3223(03)00003-9
Smaers JB, Vanier DR (2019) Brain size expansion in primates and humans is explained by a selective modular expansion of the cortico-cerebellar system. Cortex 118:292–305
pubmed: 31213287
doi: 10.1016/j.cortex.2019.04.023
Smaers JB, Gómez-Robles A, Parks AN, Sherwood CC (2017) Exceptional evolutionary expansion of prefrontal cortex in great apes and humans. Curr Biol 27:714–720
pubmed: 28162899
doi: 10.1016/j.cub.2017.01.020
Sokolov AA, Miall RC, Ivry RB (2017) The cerebellum: adaptive prediction for movement and cognition. Trends Cogn Sci 21:313–332
pubmed: 28385461
pmcid: 5477675
doi: 10.1016/j.tics.2017.02.005
Spoont MR, Kuskowski M, Pardo JV (2010) Autobiographical memories of anger in violent and non-violent individuals: a script-driven imagery study. Psychiatry Res 183:225–229
pubmed: 20702069
doi: 10.1016/j.pscychresns.2010.06.004
Sterling P, Eyer J (1988) Allostasis: a new paradigm to explain arousal pathology. In: Fisher S, Reason J (eds) Handbook of life stress, cognition and health. Wiley, New York, pp 629–649
Stoodley CJ, Schmahmann JD (2010) Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective processing. Cortex 46:831–844
pubmed: 20152963
pmcid: 2873095
doi: 10.1016/j.cortex.2009.11.008
Tiemeier H, Lenroot RK, Greenstein DK, Tran L, Pierson R, Giedd JN (2010) Cerebellum development during childhood and adolescence: a longitudinal morphometric MRI study. Neuroimage 49:63–70
pubmed: 19683586
doi: 10.1016/j.neuroimage.2009.08.016
Tinbergen N (1963) On the aims and methods of ethology. Z Tierpsychol 20:410–463
doi: 10.1111/j.1439-0310.1963.tb01161.x
Vaghi MM, Vértes PE, Kitzbichler MG, Apergis-Schoute AM, van der Flier FE, Fineberg NA, Sule A, Zaman R, Voon V, Kundu P, Bullmore ET, Robbins TW (2017) Specific frontostriatal circuits for impaired cognitive flexibility and goal-directed planning in obsessive-compulsive disorder: evidence from resting-state functional connectivity. Biol Psychiatry 81:708–717
pubmed: 27769568
pmcid: 6020061
doi: 10.1016/j.biopsych.2016.08.009
Weinshenker NJ, Siegel A (2002) Bimodal classification of aggression: affective defense and predatory attack. Aggress Violent Behav 7:237–250
doi: 10.1016/S1359-1789(01)00042-8
Wolfs EM, Klaus J, Schutter DJ (2022) Cerebellar grey matter volumes in reactive aggression and impulsivity in healthy volunteers. Cerebellum. https://doi.org/10.1007/s12311-021-01337-5
Wong TY, Sid A, Wensing T, Eickhoff SB, Habel U, Gur RC, Nickl-Jockschat T (2019) Neural networks of aggression: ALE meta-analyses on trait and elicited aggression. Brain Struct Funct 224:133–148
pubmed: 30291479
doi: 10.1007/s00429-018-1765-3
Zanchetti A, Zoccolini A (1954) Autonomic hypothalamic outbursts elicited by cerebellar stimulation. J Neurophysiol 17:475–483
pubmed: 13201979
doi: 10.1152/jn.1954.17.5.475
Zhang J, Liu W, Zhang J, Wu Q, Gao Y, Jiang Y, Gao J, Yao S, Huang B (2018) Distinguishing adolescents with conduct disorder from typically developing youngsters based on pattern classification of brain structural MRI. Front Hum Neurosci 12:152
pubmed: 29740296
pmcid: 5925967
doi: 10.3389/fnhum.2018.00152