Visualization of Inflammation in Experimental Colitis by Magnetic Resonance Imaging Using Very Small Superparamagnetic Iron Oxide Particles.
DSS-induced colitis
extracellular matrix
inflammatory bowel diseases
magnetic resonance imaging
transfer colitis
very small superparamagnetic iron oxide nanoparticles
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
25
01
2022
accepted:
16
06
2022
entrez:
29
7
2022
pubmed:
30
7
2022
medline:
30
7
2022
Statut:
epublish
Résumé
Inflammatory bowel diseases (IBD) comprise mainly ulcerative colitis (UC) and Crohn´s disease (CD). Both forms present with a chronic inflammation of the (gastro) intestinal tract, which induces excessive changes in the composition of the associated extracellular matrix (ECM). In UC, the inflammation is limited to the colon, whereas it can occur throughout the entire gastrointestinal tract in CD. Tools for early diagnosis of IBD are still very limited and highly invasive and measures for standardized evaluation of structural changes are scarce. To investigate an efficient non-invasive way of diagnosing intestinal inflammation and early changes of the ECM, very small superparamagnetic iron oxide nanoparticles (VSOPs) in magnetic resonance imaging (MRI) were applied in two mouse models of experimental colitis: the dextran sulfate sodium (DSS)-induced colitis and the transfer model of colitis. For further validation of ECM changes and inflammation, tissue sections were analyzed by immunohistochemistry. For in depth
Identifiants
pubmed: 35903065
doi: 10.3389/fphys.2022.862212
pii: 862212
pmc: PMC9315402
doi:
Types de publication
Journal Article
Langues
eng
Pagination
862212Informations de copyright
Copyright © 2022 Golusda, Kühl, Lehmann, Dahlke, Mueller, Boehm-Sturm, Saatz, Traub, Schnorr, Freise, Taupitz, Biskup, Blanchard, Klein, Sack, Siegmund and Paclik.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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