Clinical Outcomes After Ventriculo-Peritoneal Shunting in Patients With Classic vs. Complex NPH.
Alzheimer's disease
Normal Pressure Hydrocephalus (NPH)
Parkinson's disease
dementia
neurodegenerative disease
ventriculo-peritoneal shunt (VPS)
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2022
2022
Historique:
received:
01
02
2022
accepted:
13
06
2022
entrez:
29
7
2022
pubmed:
30
7
2022
medline:
30
7
2022
Statut:
epublish
Résumé
Normal pressure hydrocephalus (NPH) is a neurological condition characterized by a clinical triad of gait disturbance, cognitive impairment, and urinary incontinence in conjunction with ventriculomegaly. Other neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and vascular dementia share some overlapping clinical features. However, there is evidence that patients with comorbid NPH and Alzheimer's or Parkinson's disease may still exhibit good clinical response after CSF diversion. This study aims to evaluate clinical responses after ventriculo-peritoneal shunt (VPS) in a cohort of patients with coexisting NPH and neurodegenerative disease. The study has two components; (i) a pilot study was performed that specifically focused upon patients with Complex NPH and following the inclusion of the Complex NPH subtype into consideration for the clinical NPH programme, (ii) a retrospective snapshot study was performed to confirm and characterize differences between Classic and Complex NPH patients being seen consecutively over the course of 1 year within a working subspecialist NPH clinic. We studied the characteristics of patients with Complex NPH, utilizing clinical risk stratification and multimodal biomarkers. There was no significant difference between responders and non-responders to CSF diversion on comorbidity scales. After VPS insertion, significantly more Classic NPH patients had improved cognition compared to Complex NPH patients ( Our study has demonstrated that the presence of neurodegenerative disorders co-existing with NPH should not be the sole barrier to the consideration of high-volume tap test or lumbar drainage
Identifiants
pubmed: 35903111
doi: 10.3389/fneur.2022.868000
pmc: PMC9315242
doi:
Types de publication
Journal Article
Langues
eng
Pagination
868000Informations de copyright
Copyright © 2022 Goh, Lock, Tan, Tan, Liang, Pillay, Kumar, Ahmad-Annuar, Narayanan, Kwok, Tan, Ng, Tan, Czosnyka, Czosnyka, Pickard and Keong.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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