Persistent Non-pharmacological Pain Management and Brain-Predicted Age Differences in Middle-Aged and Older Adults With Chronic Knee Pain.
brain age
chronic musculoskeletal pain
clinical pain
knee osteoarthritis
non-pharmacological
Journal
Frontiers in pain research (Lausanne, Switzerland)
ISSN: 2673-561X
Titre abrégé: Front Pain Res (Lausanne)
Pays: Switzerland
ID NLM: 9918227269806676
Informations de publication
Date de publication:
2022
2022
Historique:
received:
02
02
2022
accepted:
22
06
2022
entrez:
29
7
2022
pubmed:
30
7
2022
medline:
30
7
2022
Statut:
epublish
Résumé
Chronic pain has been associated with changes in pain-related brain structure and function, including advanced brain aging. Non-pharmacological pain management is central to effective pain management. However, it is currently unknown how use of non-pharmacological pain management is associated with pain-related brain changes. The objective of the current study was to examine the association between brain-predicted age difference and use of non-pharmacological pain management (NPM) in a sample of middle-aged and older adults with and without chronic knee pain across two time points. One-hundred and 12 adults (mean age = 57.9 ± 8.2 years) completed sociodemographic measures, clinical pain measures, structural T1-weighted brain magnetic resonance imaging, and self-reported non-pharmacological pain management. Using a validated approach, we estimated a brain-predicted age difference (brain-PAD) biomarker, calculated as brain-predicted age minus chronological age, and the change in brain-PAD across 2 years. Repeated measures analysis of covariance was conducted to determine associations of non-pharmacological pain management and brain-PAD, adjusting for age, sex, study site, and clinical pain. There was a significant time
Identifiants
pubmed: 35903307
doi: 10.3389/fpain.2022.868546
pmc: PMC9314648
doi:
Types de publication
Journal Article
Langues
eng
Pagination
868546Subventions
Organisme : NIA NIH HHS
ID : P30 AG028740
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG067757
Pays : United States
Informations de copyright
Copyright © 2022 Johnson, Cole, Fillingim and Cruz-Almeida.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Pain. 1992 Aug;50(2):133-149
pubmed: 1408309
PLoS One. 2011;6(10):e26010
pubmed: 22022493
Br J Radiol. 2007 Dec;80 Spec No 2:S99-108
pubmed: 18445750
Neurobiol Aging. 2016 Apr;40:138-144
pubmed: 26973113
Pain. 2020 Sep 1;161(9):2167-2178
pubmed: 32379222
Neuroimage. 2016 Jul 1;134:508-513
pubmed: 27079530
Pain. 2020 Mar;161(3):641-650
pubmed: 31764393
Pain Med. 2020 Jan 1;21(1):125-137
pubmed: 31150093
Cereb Cortex. 2005 Nov;15(11):1676-89
pubmed: 15703252
Acupunct Med. 2014 Apr;32(2):102-8
pubmed: 24280949
Eur J Pain. 2011 Sep;15(8):843.e1-14
pubmed: 21315627
Pain Med. 2019 Aug 1;20(8):1489-1499
pubmed: 30541043
Mol Psychiatry. 2021 Aug;26(8):3829-3838
pubmed: 31822815
Neurology. 2005 Nov 8;65(9):1483-6
pubmed: 16275843
Mol Psychiatry. 2018 May;23(5):1385-1392
pubmed: 28439103
Pain. 2011 Mar;152(3 Suppl):S49-S64
pubmed: 21146929
J Neurosci. 2004 Nov 17;24(46):10410-5
pubmed: 15548656
Pain. 2019 May;160(5):1119-1130
pubmed: 31009418
Trends Neurosci. 2017 Dec;40(12):681-690
pubmed: 29074032
PLoS One. 2014 Sep 02;9(9):e106133
pubmed: 25180885