Structural and Functional Brain Connectivity Uniquely Contribute to Episodic Memory Performance in Older Adults.
diffusion tensor imaging
episodic memory
individual differences
multimodal neuroimaging
resting state functional connectivity
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2022
2022
Historique:
received:
23
05
2022
accepted:
15
06
2022
entrez:
29
7
2022
pubmed:
30
7
2022
medline:
30
7
2022
Statut:
epublish
Résumé
In this study, we examined the independent contributions of structural and functional connectivity markers to individual differences in episodic memory performance in 107 cognitively normal older adults from the BIOCARD study. Structural connectivity, defined by the diffusion tensor imaging (DTI) measure of radial diffusivity (RD), was obtained from two medial temporal lobe white matter tracts: the fornix and hippocampal cingulum, while functional connectivity markers were derived from network-based resting state functional magnetic resonance imaging (rsfMRI) of five large-scale brain networks: the control, default, limbic, dorsal attention, and salience/ventral attention networks. Hierarchical and stepwise linear regression methods were utilized to directly compare the relative contributions of the connectivity modalities to individual variability in a composite delayed episodic memory score, while also accounting for age, sex, cerebrospinal fluid (CSF) biomarkers of amyloid and tau pathology (i.e., Aβ
Identifiants
pubmed: 35903538
doi: 10.3389/fnagi.2022.951076
pmc: PMC9315224
doi:
Types de publication
Journal Article
Langues
eng
Pagination
951076Subventions
Organisme : NIA NIH HHS
ID : P30 AG066507
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG027668
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG033655
Pays : United States
Informations de copyright
Copyright © 2022 Alm, Soldan, Pettigrew, Faria, Hou, Lu, Moghekar, Mori, Albert and Bakker.
Déclaration de conflit d'intérêts
AM receives research support from Fujirebio Diagnostics Ltd. SM is part owner and CEO of “AnatomyWorks.” This arrangement is being managed by Johns Hopkins University in accordance with its conflict of interest policies. AB is an inventor on Johns Hopkins University intellectual property with patents pending and licensed to AgeneBio. AB’s role in the current study was in compliance with the conflict of interest policies of the Johns Hopkins University School of Medicine. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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