Changes in brain response to urgency before and after treatment of urgency urinary incontinence with onabotulinumtoxin A.
OAB
bladder control
brain
onbotulinumtoxin A
urgency urinary incontinence
Journal
Neurourology and urodynamics
ISSN: 1520-6777
Titre abrégé: Neurourol Urodyn
Pays: United States
ID NLM: 8303326
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
revised:
31
05
2022
received:
15
03
2022
accepted:
14
07
2022
pubmed:
30
7
2022
medline:
2
11
2022
entrez:
29
7
2022
Statut:
ppublish
Résumé
To better understand the role of the brain in urgency urinary incontinence (UUI), we used onabotulinumtoxin A (BoNTA) as a probe to evaluate changes in the brain's response to urgency in successful and unsuccessful treatment. Because BoNTA acts peripherally, brain changes observed should represent a reaction to changes in bladder function caused by BoNTA, or changes in the brain's compensatory mechanisms, rather than a direct effect of BoNTA on the brain. We recruited 20 women aged over 60 years with nonneurogenic UUI who were to undergo treatment with onabotulinum A toxin injected intravesically. We performed a baseline evaluation which included a 3-day bladder diary and functional magnetic resonance imaging with an urgency provocation task; we repeated this evaluation 6 weeks posttreatment. We performed an analysis of variance on a priori selected regions of interest and post hoc voxel-wise analysis on responders and nonresponders to treatment. We found a significant interaction in the right insula [F(1,18) = 5.5, p = 0.031]; activity was different during urgency provocation in responders and non-responders to therapy, before and after therapy. The supramarginal gyrus (SMG) and inferior frontal gyrus (IFG) also displayed significant interactions (p < 0.005). Activity in the periaqueductal gray and prefrontal cortex was correlated with number of leakage episodes (p < 0.05). The changes seen in the brain control mechanism after therapy likely reflect reduced bladder sensation caused by BoNTA's peripheral action. We ascribe the SMG and IFG changes to a coping mechanism for urgency which is reduced in those who respond well to treatment.
Substances chimiques
Botulinum Toxins, Type A
EC 3.4.24.69
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1703-1710Subventions
Organisme : NIA NIH HHS
ID : R56 AG059427
Pays : United States
Informations de copyright
© 2022 Wiley Periodicals LLC.
Références
Griffiths D. Neural control of micturition in humans: a working model. Review Nat Rev Urol. 2015;12(12):695-705. doi:10.1038/nrurol.2015.266
de Groat WC, Griffiths D, Yoshimura N. Neural control of the lower urinary tract. Compr Physiol. 2015;5(1):327-396. doi:10.1002/cphy.c130056
Michels L, Blok BF, Gregorini F, et al. Supraspinal control of urine storage and micturition in men-an fMRI study. Cereb Cortex. 2015;25(10):3369-3380. doi:10.1093/cercor/bhu140
Griffiths D, Clarkson B, Tadic SD, Resnick NM. Brain mechanisms underlying urge incontinence and its response to pelvic floor muscle training. J Urol. 2015;194(3):708-715. doi:10.1016/j.juro.2015.03.102
Komesu YM, Ketai LH, Mayer AR, Teshiba TM, Rogers RG. Functional magnetic resonance imaging of the brain in women with overactive bladder: brain activation during urinary urgency. Female Pelvic Med Reconstr Surg. 2011;17(1):50-54.
de Groat WC, Griffiths D, Yoshimura N. Neural control of the lower urinary tract. Comprehensive Physiology. Wiley/American Physiological Society.
Tai C, Wang J, Jin T, et al. Brain switch for reflex micturition control detected by fMRI in rats. J Neurophysiol. 2009;102(5):2719-2730. doi:10.1152/jn.00700.2009
Lin Y-H, Chiang B-J, Liao C-H. Mechanism of action of botulinum toxin A in treatment of functional urological disorders. Toxins. 2020;12(2):129. doi:10.3390/toxins12020129
Clarkson BD, Tyagi S, Griffiths DJ, Resnick NM. Test-retest repeatability of patterns of brain activation provoked by bladder filling. Neurourol Urodyn. 2017;36(6):1472-1478. doi:10.1002/nau.23153
Jo JK, Kim KN, Kim DW, Kim YT, Kim JY, Kim JY. The effect of onabotulinumtoxin A according to site of injection in patients with overactive bladder: a systematic review and meta-analysis. World J Urol. 2018;36(2):305-317. doi:10.1007/s00345-017-2121-6
MacDiarmid S, Glazier D, Shapiro A, et al. Treatment of overactive bladder with a peritrigonal injection paradigm of onabotulinumtoxin A is associated with a low incidence of clean intermittent catheterization. Neurourol Urodyn. 2019;38(S3):S123-S124.
Jenkinson M, Beckmann CF, Behrens TE, Woolrich MW, Smith SM. FSL. NeuroImage. 2012;62(2):782-790. doi:10.1016/j.neuroimage.2011.09.015
Blok BF, Sturms LM, Holstege G. Brain activation during micturition in women. Brain. 1998;121(pt 11):2033-2042.
Banihashemi L, Sheu LK, Midei AJ, Gianaros PJ. Childhood physical abuse predicts stressor-evoked activity within central visceral control regions. Soc Cogn Affect Neurosci. 2014;10(4):474-485. doi:10.1093/scan/nsu073
Uddin LQ, Yeo BTT, Spreng RN. Towards a universal taxonomy of macro-scale functional human brain networks. Brain Topogr. 2019;32(6):926-942. doi:10.1007/s10548-019-00744-6
Zhao Y, Zhang L, Rütgen M, Sladky R, Lamm C. Neural dynamics between anterior insular cortex and right supramarginal gyrus dissociate genuine affect sharing from perceptual saliency of pretended pain. eLife. 2021;10:e69994. doi:10.7554/elife.69994
Wada S, Honma M, Masaoka Y, et al. Volume of the right supramarginal gyrus is associated with a maintenance of emotion recognition ability. PLoS One. 2021;16(7):e0254623. doi:10.1371/journal.pone.0254623
Prete G, Lucafò C, Malatesta G, Tommasi L. The causal involvement of the right supramarginal gyrus in the subjective experience of time: a hf-tRNS study. Behav Brain Res. 2021;404:113157. doi:10.1016/j.bbr.2021.113157
Guidali G, Pisoni A, Bolognini N, Papagno C. Keeping order in the brain: the supramarginal gyrus and serial order in short-term memory. Cortex. 2019;119:89-99. doi:10.1016/j.cortex.2019.04.009
Liakakis G, Nickel J, Seitz RJ. Diversity of the inferior frontal gyrus-a meta-analysis of neuroimaging studies. Behav Brain Res. 2011;225(1):341-347. doi:10.1016/j.bbr.2011.06.022