A new bioinspired peptide on defensin from C. annuum fruits: Antimicrobial activity, mechanisms of action and therapeutical potential.

Animals Anti-Bacterial Agents Anti-Infective Agents Candida Defensins Fruit Mammals Peptides Reactive Oxygen Species
Anti-Candida activity Antimicrobial peptide Antimycobacterial Apoptosis-like Membrane permeabilization ROS increase

Journal

Biochimica et biophysica acta. General subjects
ISSN: 1872-8006
Titre abrégé: Biochim Biophys Acta Gen Subj
Pays: Netherlands
ID NLM: 101731726

Informations de publication

Date de publication:
11 2022
Historique:
received: 26 04 2022
revised: 12 07 2022
accepted: 22 07 2022
pubmed: 30 7 2022
medline: 31 8 2022
entrez: 29 7 2022
Statut: ppublish

Résumé

Antimicrobial peptides, natural or synthetic, appear as promising molecules for antimicrobial therapy because of their both broad antimicrobial activity and mechanism of action. Herein, we determine the anti-Candida and antimycobacterial activities, mechanism of action on yeasts, and cytotoxicity on mammalian cells in the presence of the bioinspired peptide CaDef2.1 CaDef2.1 CaDef2.1 The results obtained showed that CaDef2.1 We show a new AMP bioinspired with physicochemical characteristics important for selectivity and antimicrobial activity, which is a promising candidate for drug development, mainly to control Candida infections.

Sections du résumé

BACKGROUND
Antimicrobial peptides, natural or synthetic, appear as promising molecules for antimicrobial therapy because of their both broad antimicrobial activity and mechanism of action. Herein, we determine the anti-Candida and antimycobacterial activities, mechanism of action on yeasts, and cytotoxicity on mammalian cells in the presence of the bioinspired peptide CaDef2.1
METHODS
CaDef2.1
RESULTS
CaDef2.1
CONCLUSIONS
The results obtained showed that CaDef2.1
GENERAL SIGNIFICANCE
We show a new AMP bioinspired with physicochemical characteristics important for selectivity and antimicrobial activity, which is a promising candidate for drug development, mainly to control Candida infections.

Identifiants

DOI: 10.1016/j.bbagen.2022.130218 PMID: 35905923
pubmed: 35905923
pii: S0304-4165(22)00136-2
doi: 10.1016/j.bbagen.2022.130218
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Anti-Infective Agents 0
Defensins 0
Peptides 0
Reactive Oxygen Species 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

130218

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Auteurs

Gabriel Bonan Taveira (GB)

Laboratório de Fisiologia e Bioquímica de Microrganismos, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ 28013-602, Brazil. Electronic address: gabrielbtaveira@yahoo.com.br.

Érica de Oliveira Mello (É)

Laboratório de Fisiologia e Bioquímica de Microrganismos, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ 28013-602, Brazil.

Thatiana Lopes Biá Ventura Simão (TLBV)

Laboratório de produtos Bioativos, Universidade Federal do Rio de Janeiro, Campus Macaé, Pólo Novo Cavaleiro-IMMT, Macaé, RJ 27933-378, Brazil; Laboratório de Biologia do Reconhecer, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ 28013-602, Brazil.

Milena Bellei Cherene (MB)

Laboratório de Fisiologia e Bioquímica de Microrganismos, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ 28013-602, Brazil.

André de Oliveira Carvalho (A)

Laboratório de Fisiologia e Bioquímica de Microrganismos, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ 28013-602, Brazil.

Michelle Frazão Muzitano (MF)

Laboratório de produtos Bioativos, Universidade Federal do Rio de Janeiro, Campus Macaé, Pólo Novo Cavaleiro-IMMT, Macaé, RJ 27933-378, Brazil.

Elena Lassounskaia (E)

Laboratório de Biologia do Reconhecer, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ 28013-602, Brazil.

Saulo Pireda (S)

Laboratório de Biologia Celular e Tecidual, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ 28013-602, Brazil.

Emílio de Castro Miguel (E)

Departamento de Engenharia Metalúrgica, Universidade Federal do Ceará, Campus do Pici, Fortaleza, CE 600020-181, Brazil.

Luis Guilherme Mansor Basso (LGM)

Laboratório de Ciências Físicas, Centro de Ciência e Tecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ 28013-602, Brazil.

Maura Da Cunha (M)

Laboratório de Biologia Celular e Tecidual, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ 28013-602, Brazil.

Olney Vieira da Motta (OV)

Laboratório de Sanidade Animal, Centro de Ciências e Tecnologias Agropecuárias, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ 28013-602, Brazil.

Valdirene Moreira Gomes (VM)

Laboratório de Fisiologia e Bioquímica de Microrganismos, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ 28013-602, Brazil. Electronic address: valmg@uenf.br.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A new bioinspired peptide on defensin from C....
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › A new bioinspired peptide on defensin from C....
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › A new bioinspired peptide on defensin from C....
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Candida › A new bioinspired peptide on defensin from C....
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Perforines › Peptides antimicrobiens cationiques › Défensines › A new bioinspired peptide on defensin from C....
questionsmedicales.fr › Aliments et boissons › Aliments › Fruit › A new bioinspired peptide on defensin from C....
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › A new bioinspired peptide on defensin from C....
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › A new bioinspired peptide on defensin from C....
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › A new bioinspired peptide on defensin from C....