Sulfur mustard single-dose exposure triggers senescence in primary human dermal fibroblasts.
Human dermal fibroblasts
Senescence
Sulfur mustard
Wound healing disorder
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
received:
18
05
2022
accepted:
14
07
2022
pubmed:
30
7
2022
medline:
5
10
2022
entrez:
29
7
2022
Statut:
ppublish
Résumé
Chronic wounds, skin blisters, and ulcers are the result of skin exposure to the alkylating agent sulfur mustard (SM). One potential pathomechanism is senescence, which causes permanent growth arrest with a pro-inflammatory environment and may be associated with a chronic wound healing disorder. SM is known to induce chronic senescence in human mesenchymal stem cells which are subsequently unable to fulfill their regenerative function in the wound healing process. As dermal fibroblasts are crucial for cutaneous wound healing by being responsible for granulation tissue formation and synthesis of the extracellular matrix, SM exposure might also impair their function in a similar way. This study, therefore, investigated the SM sensitivity of primary human dermal fibroblasts (HDF) by determining the dose-response curve. Non-lethal concentrations LC
Identifiants
pubmed: 35906424
doi: 10.1007/s00204-022-03346-7
pii: 10.1007/s00204-022-03346-7
pmc: PMC9525386
doi:
Substances chimiques
Alkylating Agents
0
Cytokines
0
Mustard Gas
T8KEC9FH9P
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3053-3066Informations de copyright
© 2022. The Author(s).
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