AgRP neurons control structure and function of the medial prefrontal cortex.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
08
04
2022
accepted:
29
06
2022
revised:
28
06
2022
pubmed:
30
7
2022
medline:
7
12
2022
entrez:
29
7
2022
Statut:
ppublish
Résumé
Hypothalamic agouti-related peptide and neuropeptide Y-expressing (AgRP) neurons have a critical role in both feeding and non-feeding behaviors of newborn, adolescent, and adult mice, suggesting their broad modulatory impact on brain functions. Here we show that constitutive impairment of AgRP neurons or their peripubertal chemogenetic inhibition resulted in both a numerical and functional reduction of neurons in the medial prefrontal cortex (mPFC) of mice. These changes were accompanied by alteration of oscillatory network activity in mPFC, impaired sensorimotor gating, and altered ambulatory behavior that could be reversed by the administration of clozapine, a non-selective dopamine receptor antagonist. The observed AgRP effects are transduced to mPFC in part via dopaminergic neurons in the ventral tegmental area and may also be conveyed by medial thalamic neurons. Our results unmasked a previously unsuspected role for hypothalamic AgRP neurons in control of neuronal pathways that regulate higher-order brain functions during development and in adulthood.
Identifiants
pubmed: 35906488
doi: 10.1038/s41380-022-01691-8
pii: 10.1038/s41380-022-01691-8
pmc: PMC9891653
mid: NIHMS1866134
doi:
Substances chimiques
Agouti-Related Protein
0
Neuropeptide Y
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
3951-3960Subventions
Organisme : NIA NIH HHS
ID : R01 AG052005
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG067329
Pays : United States
Organisme : NINDS NIH HHS
ID : T32 NS007224
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Limited.
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