Changes in the liver proteome in apoE knockout mice exposed to inhalation of silica nanoparticles indicate mitochondrial damage and impairment of ER stress responses associated with microvesicular steatosis.
ApoE-knockout mice
ER stress
Liver microvesicular steatosis
Proteomics
Silica nanoparticles
Unfolded protein response
Journal
Environmental science and pollution research international
ISSN: 1614-7499
Titre abrégé: Environ Sci Pollut Res Int
Pays: Germany
ID NLM: 9441769
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
received:
16
03
2022
accepted:
20
07
2022
pubmed:
30
7
2022
medline:
7
1
2023
entrez:
29
7
2022
Statut:
ppublish
Résumé
The adverse effects of air pollution on the cardiovascular system have been well documented. Nonalcoholic fatty liver disease (NAFLD) is an independent risk factor for cardiovascular events. However, the influence of exposure to airborne particles on the development of NAFLD is less recognised. The aim of this study was to investigate the impact of silica nanoparticles (SiNPs) on the development of liver steatosis. We used molecular and proteomic SWATH-MS methods to investigate the changes in the liver proteome of apolipoprotein E-knockout mice (apoE
Identifiants
pubmed: 35906520
doi: 10.1007/s11356-022-22179-6
pii: 10.1007/s11356-022-22179-6
pmc: PMC9813169
doi:
Substances chimiques
Proteome
0
Silicon Dioxide
7631-86-9
Apolipoproteins E
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
699-709Subventions
Organisme : Narodowe Centrum Nauki
ID : APARIC 2015/16/W/ST5/00005
Informations de copyright
© 2022. The Author(s).
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