Liver transplantation in patients with acute-on-chronic liver failure.
Acute-on-chronic liver failure (ACLF)
And Child–Pugh–Turcotte (CPT)
Deceased donor liver transplant (DDLT)
Live donor liver transplant (LDLT)
Model for end-stage liver disease (MELD)
Journal
Hepatology international
ISSN: 1936-0541
Titre abrégé: Hepatol Int
Pays: United States
ID NLM: 101304009
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
18
01
2022
accepted:
15
06
2022
pubmed:
30
7
2022
medline:
5
10
2022
entrez:
29
7
2022
Statut:
ppublish
Résumé
Acute-on-chronic liver failure (ACLF) is a dynamic syndrome associated with a very high short-term mortality. Hence, the ongoing assessment of treatment response, an expedited liver transplant evaluation and listing, and the determination of futility of treatment are critical for optimal outcomes. In this review, we appraise our current understanding of the timing and futility of liver transplantation, and the short- and long-term outcomes including the quality of life after deceased or live donor liver transplantation in those with ACLF.
Identifiants
pubmed: 35906525
doi: 10.1007/s12072-022-10378-9
pii: 10.1007/s12072-022-10378-9
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
993-1000Informations de copyright
© 2022. Asian Pacific Association for the Study of the Liver.
Références
Moreau R, Jalan R, Gines P, et al. Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis. Gastroenterology. 2013;144(7):1426–1437
doi: 10.1053/j.gastro.2013.02.042
Bajaj JS, O’Leary JG, Reddy KR, et al. Survival in infection-related acute-on-chronic liver failure is defined by extrahepatic organ failures. Hepatology. 2014;60(1):250–256
doi: 10.1002/hep.27077
Jalan R, Saliba F, Pavesi M, et al. Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure. J Hepatol. 2014;61(5):1038–1047
doi: 10.1016/j.jhep.2014.06.012
Sarin SK, Choudhury A, Sharma MK, et al. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL): an update. Hepatol Int. 2019;13:353–390
doi: 10.1007/s12072-019-09946-3
Sundaram V, Jalan R, Wu T, et al. Factors associated with survival of patients with severe acute-on-chronic liver failure before and after liver transplantation. Gastroenterology. 2019;156(5):1381–1391
doi: 10.1053/j.gastro.2018.12.007
Mahmud N, Kaplan DE, Taddei TH, Goldberg DS. Incidence and mortality of acute-on-chronic liver failure using two definitions in patients with compensated cirrhosis. Hepatology. 2019;69:2150–2163
doi: 10.1002/hep.30494
Li F, Thuluvath PJ. EASL-CLIF criteria outperform NACSELD criteria for diagnosis and prognostication in ACLF. J Hepatol. 2021;75(5):1096–1103
doi: 10.1016/j.jhep.2021.05.033
Abdallah MA, Kuo YF, Asrani S, et al. Validating a novel score based on interaction between ACLF grade and MELD score to predict waitlist mortality. J Hepatol. 2021;74(6):1355–1361
doi: 10.1016/j.jhep.2020.12.003
Gustot T, Fernandez J, Garcia E, et al. Clinical course of acute-on-chronic liver failure syndrome and effects on prognosis. Hepatology. 2015;62(1):243–252
doi: 10.1002/hep.27849
Sundaram V, Shah P, Wong RJ, et al. Patients with acute on chronic liver failure grade 3 have greater 14-day waitlist mortality than status-1a patients. Hepatology. 2019;70(1):334–345
pubmed: 30908660
Sundaram V, Kogachi S, Wong RJ, et al. Effect of the clinical course of acute-on-chronic liver failure prior to liver transplantation on post-transplant survival. J Hepatol. 2020;72(3):481–488
doi: 10.1016/j.jhep.2019.10.013
Thuluvath PJ, Thuluvath AJ, Hanish S, Savva Y. Liver transplantation in patients with multiple organ failures: feasibility and outcomes. J Hepatol. 2018;69(5):1047–1056
doi: 10.1016/j.jhep.2018.07.007
Weiss E, Saner F, Asrani SK, et al. When Is a critically ill cirrhotic patient too sick to transplant? Development of consensus criteria by a multidisciplinary panel of 35 international experts. Transplantation. 2021;105(3):561–568
doi: 10.1097/TP.0000000000003364
Artzner T, Michard B, Weiss E, et al. Liver transplantation for critically ill cirrhotic patients: Stratifying utility based on pretransplant factors. Am J Transplant. 2020;20(9):2437–2448
doi: 10.1111/ajt.15852
Sundaram V, Mahmud N, Perricone G, et al. Longterm outcomes of patients undergoing liver transplantation for acute-on-chronic liver failure. Liver Transpl. 2020;26(12):1594–1602
doi: 10.1002/lt.25831
Belli LS, Duvoux C, Artzner T, et al. Liver transplantation for patients with acute-on-chronic liver failure (ACLF) in Europe: results of the ELITA/EF-CLIF collaborative study (ECLIS). J Hepatol. 2021;75(3):610–622
doi: 10.1016/j.jhep.2021.03.030
Nagel M, Labenz C, Worns MA, et al. Impact of acute-on-chronic liver failure and decompensated liver cirrhosis on psychosocial burden and quality of life of patients and their close relatives. Health Qual Life Outcomes. 2020;18(1):10
doi: 10.1186/s12955-019-1268-9
Goosmann L, Buchholz A, Bangert K, et al. Liver transplantation for acute-on-chronic liver failure predicts post-transplant mortality and impaired long-term quality of life. Liver Int. 2021;41(3):574–584
doi: 10.1111/liv.14756
Thuluvath PJ, Thuluvath AJ, Savva Y, Zhang T. Karnofsky performance status following liver transplantation in patients with multiple organ failures and probable acute-on-chronic liver failure. Clin Gastroenterol Hepatol. 2020;18(1):234–241
doi: 10.1016/j.cgh.2019.03.016
Allen AM, Kim WR, Moriarty JP, Shah ND, Larson JJ, Kamath PS. Time trends in the health care burden and mortality of acute on chronic liver failure in the United States. Hepatology. 2016;64(6):2165–2172
doi: 10.1002/hep.28812
Goussous N, Xie W, Zhang T, et al. Acute on chronic liver failure: factors associated with transplantation. Transplant Direct. 2021;7(12): e788
doi: 10.1097/TXD.0000000000001245
Jalan R, Gustot T, Fernandez J, Bernal W. ‘Equity’ and ‘Justice’ for patients with acute-on chronic liver failure: a call to action. J Hepatol. 2021;75(5):1228–1235
doi: 10.1016/j.jhep.2021.06.017
Liver transplantation in patients with cirrhosis and severe ACLF: indications and outcomes, Clinical Trials.gov, identifier: NCT04613921)
Xing T, Zhong L, Chen D, Peng Z. Experience of combined liver-kidney transplantation for acute-on-chronic liver failure patients with renal dysfunction. Transplant Proc. 2013;45(6):2307–2313
doi: 10.1016/j.transproceed.2013.02.127
Finkenstedt A, Nachbaur K, Zoller H, et al. Acute-on-chronic liver failure: excellent outcomes after liver transplantation but high mortality on the wait list. Liver Transpl. 2013;19(8):879–886
doi: 10.1002/lt.23678
Duan BW, Lu SC, Wu JS, et al. Model for end-stage (MELD) score does not predict outcomes of hepatitis B-induced acute-on-chronic liver failure in transplant recipients. Transplant Proc. 2014;46(10):3502–3506
doi: 10.1016/j.transproceed.2014.07.075
Levesque E, Winter A, Noorah Z, et al. Impact of acute-on-chronic liver failure on 90-day mortality following a first liver transplantation. Liver Int. 2017;37(5):684–693
doi: 10.1111/liv.13355
Artru F, Louvet A, Ruiz I, et al. Liver transplantation in the most severely ill cirrhotic patients: a multicenter study in acute-on-chronic liver failure grade 3. J Hepatol. 2017;67(4):708–715
doi: 10.1016/j.jhep.2017.06.009
Huebener P, Sterneck MR, Bangert K, et al. Stabilisation of acute-on-chronic liver failure patients before liver transplantation predicts post-transplant survival. Aliment Pharmacol Ther. 2018;47(11):1502–1510
doi: 10.1111/apt.14627
Marciano S, Mauro E, Giunta D, et al. Impact of acute-on-chronic liver failure on post-transplant survival and on kidney outcomes. Eur J Gastroenterol Hepatol. 2019;31(9):1157–1164
doi: 10.1097/MEG.0000000000001467
O’Leary JG, Bajaj JS, Tandon P, et al. Outcomes after listing for liver transplant in patients with acute-on-chronic liver failure: the multicenter north American consortium for the study of end-stage liver disease experience. Liver Transpl. 2019;25(4):571–579
doi: 10.1002/lt.25426
Agbim U, Sharma A, Maliakkal B, et al. Outcomes of liver transplant recipients with acute-on-chronic liver failure based on EASL-CLIF consortium definition: a single-center study. Transplant Direct. 2020;6(4): e544
doi: 10.1097/TXD.0000000000000984
Liu CL, Fan ST, Lo CM, et al. Live-donor liver transplantation for acute-on-chronic hepatitis B liver failure. Transplantation. 2003;76(8):1174–1179
doi: 10.1097/01.TP.0000087341.88471.E5
Wang YC, Yong CC, Lin CC, et al. Excellent outcome in living donor liver transplantation: treating patients with acute-on-chronic liver failure. Liver Transpl. 2021;27(11):1633–1643
doi: 10.1002/lt.26096
Moon DB, Lee SG, Kang WH, et al. Adult living donor liver transplantation for acute-on-chronic liver failure in high-model for end-stage liver disease score patients. Am J Transplant. 2017;17(7):1833–1842
doi: 10.1111/ajt.14198
Lu CY, Chen CL, Ho CM, et al. Dynamic prognostication in transplant candidates with acute-on-chronic liver failure. J Pers Med. 2020;10(4):230
doi: 10.3390/jpm10040230
Yadav SK, Saraf N, Choudhary NS, et al. Living donor liver transplantation for acute-on-chronic liver failure. Liver Transpl. 2019;25(3):459–468
pubmed: 30536705
Bhatti ABH, Dar FS, Butt MO, et al. Living donor liver transplantation for acute on chronic liver failure based on EASL-CLIF diagnostic criteria. J Clin Exp Hepatol. 2018;8(2):136–143
doi: 10.1016/j.jceh.2017.11.007