Axolotl: A resourceful vertebrate model for regeneration and beyond.
Ambystoma mexicanum
aging
cancer
immune system
regenerative medicine
transgenesis
Journal
Developmental dynamics : an official publication of the American Association of Anatomists
ISSN: 1097-0177
Titre abrégé: Dev Dyn
Pays: United States
ID NLM: 9201927
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
revised:
04
07
2022
received:
02
06
2022
accepted:
21
07
2022
pubmed:
31
7
2022
medline:
3
12
2022
entrez:
30
7
2022
Statut:
ppublish
Résumé
The regenerative capacity varies significantly among the animal kingdom. Successful regeneration program in some animals results in the functional restoration of tissues and lost structures. Among the highly regenerative animals, axolotl provides multiple experimental advantages with its many extraordinary characteristics. It has been positioned as a regeneration model organism due to its exceptional renewal capacity, including the internal organs, central nervous system, and appendages, in a scar-free manner. In addition to this unique regeneration ability, the observed low cancer incidence, its resistance to carcinogens, and the reversing effect of its cell extract on neoplasms strongly suggest its usability in cancer research. Axolotl's longevity and efficient utilization of several anti-aging mechanisms underline its potential to be employed in aging studies.
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1914-1933Informations de copyright
© 2022 American Association for Anatomy.
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