Randomized Clinical Trial of Conventional versus Indoor Daylight Photodynamic Therapy for Treatment of Actinic Cheilitis.
Actinic cheilitis
Conventional photodynamic therapy
Daylight photodynamic therapy
Indoor daylight photodynamic therapy
Photodynamic therapy
Journal
Dermatology and therapy
ISSN: 2193-8210
Titre abrégé: Dermatol Ther (Heidelb)
Pays: Switzerland
ID NLM: 101590450
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
16
05
2022
accepted:
18
07
2022
pubmed:
31
7
2022
medline:
31
7
2022
entrez:
30
7
2022
Statut:
ppublish
Résumé
Actinic cheilitis (AC) is the biologic precursor of invasive squamous cell carcinoma (SCC) of the vermilion, and different treatment options have been investigated, but their efficacy is hampered by local inflammation, pain and slow recovery. Daylight photodynamic therapy (dl-PDT) has been demonstrated to represent a valuable treatment option for AC, but its feasibility is limited by weather conditions and latitude. Our study proposed to compare the efficacy and tolerability of conventional photodynamic therapy (c-PDT) and indoor daylight photodynamic therapy (idl-PDT) with a white LED lamp for the treatment of AC. Sixteen patients were enrolled in the study: 8 (50%) treated with c-PDT and 8 (50%) treated with idl-PDT. All patients completed the study protocol. Both idl-PDT and c-PDT were demonstrated to be highly effective in terms of reduction of the cumulative lesional area and severity of the clinical score. Neither treatment was inferior to the other. The inflammatory reaction and the pain scores were milder with idl-PDT, whereas the cosmetic outcome was not different. The present findings confirm that idl-PDT can represent a valid therapeutic strategy for AC patients as well, despite the procedural difficulties and the risk of poor tolerability related to the body site.
Identifiants
pubmed: 35907163
doi: 10.1007/s13555-022-00783-1
pii: 10.1007/s13555-022-00783-1
pmc: PMC9464288
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2049-2061Informations de copyright
© 2022. The Author(s).
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