Prevention of delirium with agitation by yokukansan in older adults after cancer surgery.
clinical trial
gerontology
psycho-oncology
surgical oncology
Journal
Japanese journal of clinical oncology
ISSN: 1465-3621
Titre abrégé: Jpn J Clin Oncol
Pays: England
ID NLM: 0313225
Informations de publication
Date de publication:
03 Nov 2022
03 Nov 2022
Historique:
received:
31
05
2022
accepted:
14
07
2022
pubmed:
31
7
2022
medline:
5
11
2022
entrez:
30
7
2022
Statut:
ppublish
Résumé
Preventing postoperative delirium with agitation is vital in the older population. We examined the preventive effect of yokukansan on postoperative delirium with agitation in older adult patients undergoing highly invasive cancer resection. We performed a secondary per-protocol analysis of 149 patients' data from a previous clinical trial. Patients underwent scheduled yokukansan or placebo intervention 4-8 days presurgery and delirium assessment postoperatively. Delirium with agitation in patients aged ≥75 years was assessed using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, and the Japanese version of the Delirium Rating Scale-Revised-98. We assessed odds ratios for yokukansan (TJ-54) compared with placebo for the manifestation of postoperative delirium with agitation across patients of all ages (n = 149) and those aged ≥65 years (n = 82) and ≥ 75 years (n = 21) using logistic regression. Delirium with agitation manifested in 3/14 and 5/7 patients in the TJ-54 and placebo groups, respectively, among those aged ≥75 years. The odds ratio for yokukansan vs. placebo was 0.11 (95% confidence interval: 0.01-0.87). An age and TJ-54 interaction effect was detected in patients with delirium with agitation. No intergroup differences were observed in patients aged ≥65 years or across all ages for delirium with agitation. This is the first study investigating the preventive effect of yokukansan on postoperative delirium with agitation in older adults. Yokukansan may alleviate workforce burdens in older adults caused by postoperative delirium with agitation following highly invasive cancer resection.
Identifiants
pubmed: 35907781
pii: 6652299
doi: 10.1093/jjco/hyac123
pmc: PMC9631458
doi:
Substances chimiques
Drugs, Chinese Herbal
0
Yi-Gan San
0
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
1276-1281Subventions
Organisme : Research on Development of New Drugs
ID : JP21ak0101160
Organisme : Japan Agency for Medical Research and Development
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press.
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