Leveraging antigenic seniority for maternal vaccination to prevent mother-to-child transmission of HIV-1.
Journal
NPJ vaccines
ISSN: 2059-0105
Titre abrégé: NPJ Vaccines
Pays: England
ID NLM: 101699863
Informations de publication
Date de publication:
30 Jul 2022
30 Jul 2022
Historique:
received:
30
05
2021
accepted:
01
07
2022
entrez:
30
7
2022
pubmed:
31
7
2022
medline:
31
7
2022
Statut:
epublish
Résumé
The development of a maternal HIV vaccine to synergize with current antiretroviral drug prophylaxis can overcome implementation challenges and further reduce mother-to-child transmission (MTCT) of HIV. Both the epitope-specificity and autologous neutralization capacity of maternal HIV envelope (Env)-specific antibodies have been implicated in decreased risk of MTCT of HIV. Our goal was to determine if heterologous HIV Env immunization of SHIV.C.CH505-infected, ART-suppressed female rhesus macaques (RMs) could boost autologous Env-specific antibodies. SHIV.C.CH505-infected female RMs (n = 12), began a daily ART regimen at 12 weeks post-infection (wpi), which was continued for 12 weeks. Starting 2 weeks after ART initiation, RMs received 3 monthly immunizations with HIV b.63521/1086.C gp120 or placebo (n = 6/group) vaccine with adjuvant STR8S-C. Compared to the placebo-immunized animals, Env-vaccinated, SHIV-infected RMs exhibited enhanced IgG binding, avidity, and ADCC responses against the vaccine immunogens and the autologous SHIV.C.CH505 Env. Notably, the Env-specific memory B cells elicited by heterologous vaccination were dominated by cells that recognized the SHIV.C.CH505 Env, the antigen of primary exposure. Thus, vaccination of SHIV-infected, ART-suppressed RMs with heterologous HIV Envs can augment multiple components of the antibody response against the Env antigen of primary exposure, suggesting antigenic seniority. Our results suggest that a universal maternal HIV vaccination regimen can be developed to leverage antigenic seniority in targeting the maternal autologous virus pool.
Identifiants
pubmed: 35907918
doi: 10.1038/s41541-022-00505-w
pii: 10.1038/s41541-022-00505-w
pmc: PMC9338948
doi:
Types de publication
Journal Article
Langues
eng
Pagination
87Subventions
Organisme : NIAID NIH HHS
ID : P01 AI131251
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI165080
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI117915
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)
ID : 7P01AI117915-07
Organisme : NIAID NIH HHS
ID : R01 AI160607
Pays : United States
Informations de copyright
© 2022. The Author(s).
Références
J Virol. 1997 Mar;71(3):2233-40
pubmed: 9032358
J Immunol Methods. 2014 Jul;409:131-46
pubmed: 24291345
Immunity. 2013 Jan 24;38(1):176-86
pubmed: 23313589
J Virol. 2012 Apr;86(8):4129-38
pubmed: 22301151
J Acquir Immune Defic Syndr. 2002 Apr 15;29(5):435-40
pubmed: 11981358
mSphere. 2018 Jan 10;3(1):
pubmed: 29359183
AIDS. 2010 Nov 27;24(18):2803-8
pubmed: 20962613
Top Antivir Med. 2015 May-Jun;23(2):80-4
pubmed: 26200707
J Infect Dis. 2000 Oct;182(4):1243-6
pubmed: 10979926
J Virol. 2020 Sep 15;94(19):
pubmed: 32669328
Curr HIV Res. 2009 Jan;7(1):2-11
pubmed: 19149549
J Virol. 1995 Feb;69(2):1001-12
pubmed: 7815476
J Infect Dis. 1998 May;177(5):1247-59
pubmed: 9593009
J Virol. 2002 Dec;76(24):12845-54
pubmed: 12438610
Proc Natl Acad Sci U S A. 1989 Oct;86(20):8055-8
pubmed: 2479014
Nat Commun. 2019 Apr 10;10(1):1660
pubmed: 30971703
mBio. 2020 Mar 10;11(2):
pubmed: 32156815
J Virol. 2014 Mar;88(6):3329-39
pubmed: 24390332
mBio. 2019 Sep 5;10(5):
pubmed: 31488511
J Acquir Immune Defic Syndr. 2019 Aug 15;81(5):594-599
pubmed: 31045647
Cell Host Microbe. 2019 Jul 10;26(1):73-85.e4
pubmed: 31295427
J Virol. 2019 Jul 17;93(15):
pubmed: 31092583
J Virol. 2018 Sep 26;92(20):
pubmed: 30089691
J Immunol Methods. 2014 Feb;404:1-12
pubmed: 24316020
Immunol Rev. 2020 Jul;296(1):191-204
pubmed: 32666572
Blood. 1997 Aug 1;90(3):1109-14
pubmed: 9242542
PLoS Pathog. 2012;8(7):e1002802
pubmed: 22829765
Nat Med. 2016 Sep;22(9):1043-9
pubmed: 27500724
Curr Opin HIV AIDS. 2007 Sep;2(5):367-74
pubmed: 19372914
J Virol. 2006 Jul;80(13):6525-33
pubmed: 16775339
J Virol. 2008 Dec;82(24):12449-63
pubmed: 18842730
Sci Transl Med. 2017 Sep 6;9(406):
pubmed: 28878010
Open Forum Infect Dis. 2016 May 19;3(2):ofw100
pubmed: 27419172
N Engl J Med. 2013 Nov 7;369(19):1828-35
pubmed: 24152233
J Virol. 2008 Apr;82(8):3952-70
pubmed: 18256145
AIDS. 1989 Sep;3(9):577-82
pubmed: 2551341
J Virol. 2019 Mar 21;93(7):
pubmed: 30651354
Curr HIV Res. 2013 Mar;11(2):144-59
pubmed: 23432490
Nat Commun. 2017 Nov 23;8(1):1732
pubmed: 29170366
Nature. 2016 Dec 8;540(7632):284-287
pubmed: 27841870
Clin Vaccine Immunol. 2017 Aug 4;24(8):
pubmed: 28566336
Methods Mol Biol. 2009;485:395-405
pubmed: 19020839
J Virol. 1999 Nov;73(11):8966-74
pubmed: 10516002
AIDS Rev. 2020 Oct 26;23(1):28-39
pubmed: 33105471
N Engl J Med. 2012 Apr 5;366(14):1275-86
pubmed: 22475592
Cell Host Microbe. 2015 Apr 8;17(4):500-6
pubmed: 25856755
BMC Infect Dis. 2019 Sep 16;19(Suppl 1):789
pubmed: 31526366
J Virol. 2017 Jul 12;91(15):
pubmed: 28539449
Cytometry A. 2011 Aug;79(8):603-12
pubmed: 21735545
J Virol. 2020 Oct 14;94(21):
pubmed: 32817214
J Virol. 2015 Oct;89(19):9952-61
pubmed: 26202232
PLoS Pathog. 2012;8(6):e1002739
pubmed: 22719248
Trends Immunol. 2018 Jan;39(1):70-79
pubmed: 28867526
J Clin Invest. 1995 Feb;95(2):732-7
pubmed: 7860754
J Virol. 2020 Apr 16;94(9):
pubmed: 32075936
Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):E3413-22
pubmed: 27247400
J Virol. 2003 Feb;77(4):2736-40
pubmed: 12552014
J Infect Dis. 2014 Nov 15;210(10):1529-38
pubmed: 24850788
J Virol. 2006 Sep;80(18):9217-25
pubmed: 16940533
J Virol. 2006 Jan;80(2):835-44
pubmed: 16378985
J Virol. 2005 Aug;79(16):10108-25
pubmed: 16051804
J Int AIDS Soc. 2017 Dec;20(4):
pubmed: 29282882
AIDS Res Hum Retroviruses. 2016 Feb;32(2):163-8
pubmed: 26150024
PLoS Pathog. 2018 Apr 19;14(4):e1006944
pubmed: 29672607
Mol Biol Evol. 2016 Jul;33(7):1870-4
pubmed: 27004904
J Clin Invest. 2015 Jul 1;125(7):2702-6
pubmed: 26053661
Vaccine X. 2019 Jun 20;2:100029
pubmed: 31384744
Mol Biol Evol. 2010 Feb;27(2):221-4
pubmed: 19854763
mBio. 2017 Oct 24;8(5):
pubmed: 29066544
Blood. 2009 Apr 16;113(16):3716-25
pubmed: 19018092
Nat Med. 2020 Apr;26(4):498-501
pubmed: 32235883
J Virol. 2021 Apr 12;95(9):
pubmed: 33568508