The Alzheimer's Association appropriate use recommendations for blood biomarkers in Alzheimer's disease.

Humans Alzheimer Disease / diagnostic imaging Biomarkers / cerebrospinal fluid Prognosis Positron-Emission Tomography Longitudinal Studies Amyloid beta-Peptides / cerebrospinal fluid tau Proteins / cerebrospinal fluid Cognitive Dysfunction / cerebrospinal fluid Peptide Fragments / cerebrospinal fluid
Alzheimer's disease appropriate use recommendations blood-based biomarkers diagnosis prognosis

Journal

Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978

Informations de publication

Date de publication:
12 2022
Historique:
revised: 28 06 2022
received: 11 05 2022
accepted: 08 07 2022
pubmed: 1 8 2022
medline: 3 1 2023
entrez: 31 7 2022
Statut: ppublish

Résumé

Blood-based markers (BBMs) have recently shown promise to revolutionize the diagnostic and prognostic work-up of Alzheimer's disease (AD), as well as to improve the design of interventional trials. Here we discuss in detail further research needed to be performed before widespread use of BBMs. We already now recommend use of BBMs as (pre-)screeners to identify individuals likely to have AD pathological changes for inclusion in trials evaluating disease-modifying therapies, provided the AD status is confirmed with positron emission tomography (PET) or cerebrospinal fluid (CSF) testing. We also encourage studying longitudinal BBM changes in ongoing as well as future interventional trials. However, BBMs should not yet be used as primary endpoints in pivotal trials. Further, we recommend to cautiously start using BBMs in specialized memory clinics as part of the diagnostic work-up of patients with cognitive symptoms and the results should be confirmed whenever possible with CSF or PET. Additional data are needed before use of BBMs as stand-alone diagnostic AD markers, or before considering use in primary care.

Identifiants

DOI: 10.1002/alz.12756 PMID: 35908251 PMC: PMC10087669
pubmed: 35908251
doi: 10.1002/alz.12756
pmc: PMC10087669
doi:

Substances chimiques

Biomarkers 0
Amyloid beta-Peptides 0
tau Proteins 0
Peptide Fragments 0

Types de publication

Journal Article Review Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2669-2686

Subventions

Organisme : NIA NIH HHS
ID : U01 AG045390
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG063911
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062422
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG061848
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG063689
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054029
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG038791
Pays : United States
Organisme : NINDS NIH HHS
ID : U54 NS092089
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG036694
Pays : United States
Organisme : NIA NIH HHS
ID : R35 AG072362
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG053798
Pays : United States
Organisme : NIA NIH HHS
ID : U24 AG057437
Pays : United States

Informations de copyright

© 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

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Auteurs

Oskar Hansson (O)

Clinical, Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Memory Clinic, Skåne University Hospital, Malmö, Sweden.

Rebecca M Edelmayer (RM)

Alzheimer's Association, Chicago, Illinois, USA.

Adam L Boxer (AL)

Department of Neurology, University of California San Francisco, Memory and Aging Center, San Francisco, California, USA.

Maria C Carrillo (MC)

Alzheimer's Association, Chicago, Illinois, USA.

Michelle M Mielke (MM)

Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

Gil D Rabinovici (GD)

Department of Neurology, University of California San Francisco, Memory and Aging Center, San Francisco, California, USA.

Stephen Salloway (S)

Departments of Neurology and Psychiatry, Alpert Medical School of Brown University, Providence, Rhode Island, USA.

Reisa Sperling (R)

Center, for Alzheimer Research and Treatment, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Henrik Zetterberg (H)

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.
UK Dementia Research Institute at UCL, London, UK.
Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, People's Republic of China.

Charlotte E Teunissen (CE)

Neurochemistry, Laboratory, Department of Clinical Chemistry, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam Neuroscience, Amsterdam, the Netherlands.

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