Malignant oligoastrocytoma in the spinal cord of a cat.
Ki-67
cat
oligoastrocytoma
spinal cord
tumor
Journal
The Journal of veterinary medical science
ISSN: 1347-7439
Titre abrégé: J Vet Med Sci
Pays: Japan
ID NLM: 9105360
Informations de publication
Date de publication:
12 Sep 2022
12 Sep 2022
Historique:
pubmed:
1
8
2022
medline:
14
9
2022
entrez:
31
7
2022
Statut:
ppublish
Résumé
A 12-year and 3-month spayed female mixed cat was presented with severe lumbar pain. Magnetic resonance imaging and postmortem examination revealed a swollen lesion in the spinal cord at L3 level. Histologic examination identified extensive neoplastic cell proliferation with massive necrosis in the tumor tissue. Two types of neoplastic cells were recognized. One type of neoplastic cells were large cells characterized by round to polygonal shape and abundant eosinophilic cytoplasm (referred to as "large cells"). The other neoplastic cells were small, densely proliferated, and had round to irregular shape and scant eosinophilic cytoplasm (referred to as "small cells"). Both types of cells were positive for oligodendrocyte transcription factor 2 and SRY-box transcription factor 10. Glial fibrillary acidic protein was positive in large cells but negative in most small cells. Digital analysis for Ki-67-stained tumor tissues found that total 21.1% ± 6.5% of tumor cells were positive for Ki-67. Based on these findings, we diagnosed malignant oligoastrocytoma in the spinal cord.
Identifiants
pubmed: 35908858
doi: 10.1292/jvms.22-0144
pmc: PMC9523307
doi:
Substances chimiques
Ki-67 Antigen
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1277-1282Références
Mol Cancer Res. 2007 Sep;5(9):891-7
pubmed: 17855658
Exp Eye Res. 2021 Jan;202:108315
pubmed: 33091431
J Vet Intern Med. 2004 Nov-Dec;18(6):851-8
pubmed: 15638269
J Feline Med Surg. 2017 Dec;19(12):1307-1314
pubmed: 28156189
Arch Pathol Lab Med. 2019 Feb;143(2):222-234
pubmed: 30307746
Genes Dev. 2002 Jan 15;16(2):165-70
pubmed: 11799060
Surg Neurol. 2004 Jan;61(1):77-81; discussion 81
pubmed: 14706386
J Am Vet Med Assoc. 2008 Jan 15;232(2):237-43
pubmed: 18275391
J Vet Med Sci. 2010 Jan;72(1):99-102
pubmed: 19915332
Sci Rep. 2017 Dec 4;7(1):16878
pubmed: 29203879
J Vet Diagn Invest. 2014 Jul;26(4):513-520
pubmed: 24821692
Mol Med Rep. 2015 Mar;11(3):1566-72
pubmed: 25384676
Vet Pathol. 1982 Nov;19(6):713-5
pubmed: 7147631
Cell. 2002 Apr 5;109(1):75-86
pubmed: 11955448
J Neurooncol. 2006 Jan;76(2):115-27
pubmed: 16205963
J Vet Intern Med. 2016 Mar-Apr;30(2):617-26
pubmed: 26846816
Dev Biol. 2006 May 15;293(2):358-69
pubmed: 16581057
Cancer. 2001 Nov 15;92(10):2720-6
pubmed: 11745208
J Neurosci. 1998 Jan 1;18(1):237-50
pubmed: 9412504
J Neuropathol Exp Neurol. 2004 May;63(5):499-509
pubmed: 15198128
Vet J. 2016 Oct;216:109-16
pubmed: 27687936
Cell. 2002 Apr 5;109(1):61-73
pubmed: 11955447
J Small Anim Pract. 2001 Jun;42(6):306-10
pubmed: 11440402
J Neurosci. 2008 Oct 8;28(41):10434-42
pubmed: 18842903
Vet Pathol. 2014 Jan;51(1):146-60
pubmed: 24280940
Lab Invest. 2019 Jan;99(1):107-117
pubmed: 30181553