Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
31 07 2022
31 07 2022
Historique:
received:
27
10
2021
accepted:
27
07
2022
entrez:
31
7
2022
pubmed:
1
8
2022
medline:
3
8
2022
Statut:
epublish
Résumé
We tested the causality between education and smoking using the natural experiment of discordant twin pairs allowing to optimally control for background genetic and childhood social factors. Data from 18 cohorts including 10,527 monozygotic (MZ) and same-sex dizygotic (DZ) twin pairs discordant for education and smoking were analyzed by linear fixed effects regression models. Within twin pairs, education levels were lower among the currently smoking than among the never smoking co-twins and this education difference was larger within DZ than MZ pairs. Similarly, education levels were higher among former smoking than among currently smoking co-twins, and this difference was larger within DZ pairs. Our results support the hypothesis of a causal effect of education on both current smoking status and smoking cessation. However, the even greater intra-pair differences within DZ pairs, who share only 50% of their segregating genes, provide evidence that shared genetic factors also contribute to these associations.
Identifiants
pubmed: 35909142
doi: 10.1038/s41598-022-17536-x
pii: 10.1038/s41598-022-17536-x
pmc: PMC9339539
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
13148Subventions
Organisme : NIA NIH HHS
ID : R01 AG022982
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG018386
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG039572
Pays : United States
Organisme : NIAAA NIH HHS
ID : K05 AA000145
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG076838
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA012502
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA009203
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG018384
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG050595
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG022381
Pays : United States
Organisme : NIAAA NIH HHS
ID : R37 AA012502
Pays : United States
Informations de copyright
© 2022. The Author(s).
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