MHC class II genotype-by-pathogen genotype interaction for infection prevalence in a natural rodent-Borrelia system.
Borrelia
Myodes glareolus
coevolution
frequency-dependent selection
ospC
Journal
Evolution; international journal of organic evolution
ISSN: 1558-5646
Titre abrégé: Evolution
Pays: United States
ID NLM: 0373224
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
revised:
25
05
2022
received:
23
02
2022
accepted:
11
07
2022
pubmed:
2
8
2022
medline:
9
9
2022
entrez:
1
8
2022
Statut:
ppublish
Résumé
MHC genes are extraordinarily polymorphic in most taxa. Host-pathogen coevolution driven by negative frequency-dependent selection (NFDS) is one of the main hypotheses for the maintenance of such immunogenetic variation. Here, we test a critical but rarely tested assumption of this hypothesis-that MHC alleles affect resistance/susceptibility to a pathogen in a strain-specific way, that is, there is a host genotype-by-pathogen genotype interaction. In a field study of bank voles naturally infected with the tick-transmitted bacterium Borrelia afzelii, we tested for MHC class II (DQB) genotype-by-B. afzelii strain interactions for infection prevalence between 10 DQB alleles and seven strains. One allele (DQB*37) showed an interaction, such that voles carrying DQB*37 had higher prevalence of two strains and lower prevalence of one strain than individuals without the allele. These findings were corroborated by analyses of strain composition of infections, which revealed an effect of DQB*37 in the form of lower β diversity among infections in voles carrying the allele. Taken together, these results provide rare support at the molecular genetic level for a key assumption of models of antagonistic coevolution through NFDS.
Identifiants
pubmed: 35909235
doi: 10.1111/evo.14590
pmc: PMC9541904
doi:
Banques de données
Dryad
['10.5061/dryad.fttdz08w9']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2067-2075Informations de copyright
© 2022 The Authors. Evolution published by Wiley Periodicals LLC on behalf of The Society for the Study of Evolution.
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