Suppression of influenza virus infection by rhinovirus interference - at the population, individual and cellular levels.
Co-infection
Influenza
Rhinovirus
Viral epidemiology
Viral interference
Journal
Current research in microbial sciences
ISSN: 2666-5174
Titre abrégé: Curr Res Microb Sci
Pays: Netherlands
ID NLM: 101773003
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
1
8
2022
pubmed:
2
8
2022
medline:
2
8
2022
Statut:
epublish
Résumé
Influenza virus (IV) and the rhinovirus (RV) are the two most common circulating respiratory viruses circulating. Natural viral interference has been suggested between them. The effect of such at the population level has been described in temperate region, while its effect at the individual and cellular levels warrants further validation. In this study, we described the respiratory virus epidemiology and the co-infection landscape in the hospitalized population and investigated the distinct molecular pathways involved in the inhibition of virus replication. Nasopharyngeal aspirates (NPAs) collected from patients during 2015 to 2019 were examined for the presence of respiratory viruses. The correlation of the monthly prevalence between all the tested respiratory viruses, the co-infection rate and the temporal interference of RV and IV were tested. The viral interference was validated A total of 112,926 NPAs were evaluated, and the Enterovirus/RV was the most prevalent respiratory virus detected. The negative correlation between EV/RV and IVs prevalence was independent of age and meteorological factors. Compare with other viruses, EV/RV had a significantly lower incidence of co-infection with IVs. Prior exposure to RV inhibited the replication of IV species A, B and oseltamivir-resistance stain Epidemiological surveillance and the sequential infection This study was supported by the General Research Fund (Ref: 24107017 and 14103119 to RWYC) and the Chinese University Direct Grant for Research (Ref: 2019·073 to RWYC).
Sections du résumé
Background
UNASSIGNED
Influenza virus (IV) and the rhinovirus (RV) are the two most common circulating respiratory viruses circulating. Natural viral interference has been suggested between them. The effect of such at the population level has been described in temperate region, while its effect at the individual and cellular levels warrants further validation. In this study, we described the respiratory virus epidemiology and the co-infection landscape in the hospitalized population and investigated the distinct molecular pathways involved in the inhibition of virus replication.
Methods
UNASSIGNED
Nasopharyngeal aspirates (NPAs) collected from patients during 2015 to 2019 were examined for the presence of respiratory viruses. The correlation of the monthly prevalence between all the tested respiratory viruses, the co-infection rate and the temporal interference of RV and IV were tested. The viral interference was validated
Findings
UNASSIGNED
A total of 112,926 NPAs were evaluated, and the Enterovirus/RV was the most prevalent respiratory virus detected. The negative correlation between EV/RV and IVs prevalence was independent of age and meteorological factors. Compare with other viruses, EV/RV had a significantly lower incidence of co-infection with IVs. Prior exposure to RV inhibited the replication of IV species A, B and oseltamivir-resistance stain
Interpretation
UNASSIGNED
Epidemiological surveillance and the sequential infection
Funding
UNASSIGNED
This study was supported by the General Research Fund (Ref: 24107017 and 14103119 to RWYC) and the Chinese University Direct Grant for Research (Ref: 2019·073 to RWYC).
Identifiants
pubmed: 35909608
doi: 10.1016/j.crmicr.2022.100147
pii: S2666-5174(22)00044-X
pmc: PMC9325905
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100147Informations de copyright
© 2022 The Author(s).
Déclaration de conflit d'intérêts
The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Renee WY Chan reports financial support was provided by University Grants Committee Research Grants Council. Renee WY Chan reports financial support was provided by Hong Kong Food and Health Bureau. Renee WY Chan reports financial support was provided by The Chinese University of Hong Kong Faculty of Medicine.
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