Intranasally applied human olfactory mucosa neural progenitor cells migrate to damaged brain regions.
brain injury
homing
intranasal delivery
olfactory mucosa
progenitor cells
stem cells
Journal
Future science OA
ISSN: 2056-5623
Titre abrégé: Future Sci OA
Pays: England
ID NLM: 101665030
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
02
03
2022
accepted:
27
06
2022
entrez:
1
8
2022
pubmed:
2
8
2022
medline:
2
8
2022
Statut:
epublish
Résumé
To determine if intranasally administered olfactory mucosa progenitor cells (OMPCs) migrate to damaged areas of brain. Rowett Nude (RNU) adult rats were injured using the Marmarou model then 2 weeks later received intranasally-delivered human OMPC. After 3 weeks, rats were sacrificed and brain sectioned. The mean distances from the human OMPCs to markers for degenerative neuronal cell bodies (p-c-Jun The human OMPCs were seen in specific areas of the brain near degenerating cell bodies and damaged axons. Intranasally delivered human OMPC selectively migrate to brain injury sites suggesting a possible noninvasive stem cell delivery for brain injury.
Identifiants
pubmed: 35909995
doi: 10.2144/fsoa-2022-0012
pmc: PMC9327642
doi:
Types de publication
Journal Article
Langues
eng
Pagination
FSO806Informations de copyright
© 2022 The Authors.
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