Central Nervous System Xanthoma Disseminatum: Response to 2CdA in an Adolescent.
Journal
Case reports in pediatrics
ISSN: 2090-6803
Titre abrégé: Case Rep Pediatr
Pays: United States
ID NLM: 101581030
Informations de publication
Date de publication:
2022
2022
Historique:
received:
03
11
2021
accepted:
15
06
2022
entrez:
1
8
2022
pubmed:
2
8
2022
medline:
2
8
2022
Statut:
epublish
Résumé
Xanthoma disseminatum is a normolipemic non-Langerhans cell histiocytosis characterized by red-brown rubbery papules of the skin which coalesce into plaque-like lesions with symmetric involvement of face, flexor, and intertriginous areas. Less commonly, xanthoma disseminatum may affect mucosal linings, abdominal organs, and the central nervous system, leading to endocrinopathies. We report a 12-year-old adolescent with mucosal, central nervous system, and painful cutaneous lesions, further complicated by diabetes insipidus and amenorrhea. Treatment with 2-chlorodeoxyadenosine led to relief of pain and significant improvement of mucosal, central nervous system, and cutaneous lesions, with subsequent restoration of menstrual cycles.
Identifiants
pubmed: 35910691
doi: 10.1155/2022/9906668
pmc: PMC9337940
doi:
Types de publication
Case Reports
Langues
eng
Pagination
9906668Informations de copyright
Copyright © 2022 Patrick DeMoss et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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