Antibiofilm Synergistic Activity of Streptomycin in Combination with Thymol-Loaded Poly (Lactic-co-glycolic Acid) Nanoparticles against
Journal
Evidence-based complementary and alternative medicine : eCAM
ISSN: 1741-427X
Titre abrégé: Evid Based Complement Alternat Med
Pays: United States
ID NLM: 101215021
Informations de publication
Date de publication:
2022
2022
Historique:
received:
19
04
2022
revised:
12
06
2022
accepted:
01
07
2022
entrez:
1
8
2022
pubmed:
2
8
2022
medline:
2
8
2022
Statut:
epublish
Résumé
Thymol is an important component of essential oils found in the oil of thyme, is extracted mainly from The broth microdilution method was used to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The antibiofilm activities were determined by the safranin dye assay. The synergistic effect of Thy-NPs with streptomycin was assessed by the checkerboard method. The kinetic study of the biofilm biomass and time-kill assay were further performed. Thy-NPs exhibited the highest antibacterial activity against Our results indicate that the synergistic bactericidal effect between streptomycin and Thy-NPs could be a promising approach in the control of biofilm-associated infections caused by
Sections du résumé
Background
UNASSIGNED
Thymol is an important component of essential oils found in the oil of thyme, is extracted mainly from
Methods
UNASSIGNED
The broth microdilution method was used to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The antibiofilm activities were determined by the safranin dye assay. The synergistic effect of Thy-NPs with streptomycin was assessed by the checkerboard method. The kinetic study of the biofilm biomass and time-kill assay were further performed.
Results
UNASSIGNED
Thy-NPs exhibited the highest antibacterial activity against
Conclusions
UNASSIGNED
Our results indicate that the synergistic bactericidal effect between streptomycin and Thy-NPs could be a promising approach in the control of biofilm-associated infections caused by
Identifiants
pubmed: 35911151
doi: 10.1155/2022/1936165
pmc: PMC9334066
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1936165Informations de copyright
Copyright © 2022 Borel Ndezo Bisso et al.
Déclaration de conflit d'intérêts
The authors declare that there are no conflicts of interest regarding the publication of this paper.
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