The Role and Effectiveness of Photodynamic Therapy on Patients With Actinic Keratosis: A Systematic Review and Meta-Analysis.

actinic keratosis bf-200 ala c-pdt daylight pdt mal-pdt photodynamic therapy

Journal

Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737

Informations de publication

Date de publication:
Jun 2022
Historique:
accepted: 28 06 2022
entrez: 1 8 2022
pubmed: 2 8 2022
medline: 2 8 2022
Statut: epublish

Résumé

Actinic keratoses (AKs) are the most common neoplastic lesions and are recognized as a precursor to squamous cell skin cancer. Photodynamic therapy (PDT) is a therapeutic option for multiple AKs in line with field cancerization. The aim of this study was to assess the effectiveness of PDT on patients with AKs using a meta-analysis, in order to evaluate the possible superiority of one treatment over the others. For this purpose, the PubMed, MEDLINE, Scopus, OVID, Science Direct, British Journal of Dermatology, Research Gate, and Embase databases were searched in March 2022. The search terms used were 'photodynamic therapy' and 'actinic keratosis'. We utilized the random-effects meta-analysis model to compare methyl aminolevulinate PDT (MAL-PDT) and the combination of a nanoscale-lipid vesicle formulation with the prodrug 5-aminolevulinic acid (BF-200 ALA) on a complete response (CR) of the lesions. Our meta-analysis indicated that the comparison of BF-200 ALA versus MAL-PDT showed marginally higher CRs than MAL-PDT.

Identifiants

pubmed: 35911353
doi: 10.7759/cureus.26390
pmc: PMC9332024
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

e26390

Informations de copyright

Copyright © 2022, Mpourazanis et al.

Déclaration de conflit d'intérêts

The authors have declared that no competing interests exist.

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Auteurs

George Mpourazanis (G)

Department of Obstetrics and Gynecology, General Hospital of Ioannina G. Hatzikosta, Ioannina, GRC.

Wolfgang Konschake (W)

Department of Dermatology, Ernst-Moritz-Arndt Medical University of Greifswald, Greifswald, DEU.

Romanos Vogiatzis (R)

Department of Dermatology, Ernst-Moritz-Arndt Medical University of Greifswald, Greifswald, DEU.

Petros Papalexis (P)

Department of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, GRC.
Unit of Endocrinology, First Department of Internal Medicine, Laiko General Hospital, National and Kapodistrian University of Athens, Athens, GRC.

Vasiliki E Georgakopoulou (VE)

Department of Pulmonology, Laiko General Hospital, Athens, GRC.
First Department of Pulmonology, Sismanogleio Hospital, Athens, GRC.

Georgios Ntritsos (G)

Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, GRC.
Department of Informatics and Telecommunications, School of Informatics and Telecommunications, University of Ioannina, Arta, GRC.

Pagona Sklapani (P)

Department of Cytology, Mitera-Hygeia Hospital, Athens, GRC.

Nikolaos Trakas (N)

Department of Biochemistry, Sismanogleio Hospital, Athens, GRC.

Classifications MeSH