Prevalence of Long COVID-19 Symptoms After Hospital Discharge in Frail and Robust Patients.

COVID-19 frailty long COVID-19 syndrome older people prevalence

Journal

Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047

Informations de publication

Date de publication:
2022
Historique:
received: 13 12 2021
accepted: 10 06 2022
entrez: 1 8 2022
pubmed: 2 8 2022
medline: 2 8 2022
Statut: epublish

Résumé

A motley postacute symptomatology may develop after COVID-19, irrespective of the acute disease severity, age, and comorbidities. Frail individuals have reduced physiological reserves and manifested a worse COVID-19 course, during the acute setting. However, it is still unknown, whether frailty may subtend some long COVID-19 manifestations. We explored the prevalence of long COVID-19 disturbs in COVID-19 survivals. This was an observational study. Patients aged 65 years or older were followed-up 1, 3, and 6 months after hospitalization for COVID-19 pneumonia. A total of 382 patients were enrolled. Frail patients were more malnourished (median Mini Nutritional Assessment Short Form score 8 vs. 9, The precocious identification of frail COVID-19 survivors, who manifest more motor and respiratory complaints during the follow-up, could improve the long-term management of these COVID-19 sequelae.

Sections du résumé

Background UNASSIGNED
A motley postacute symptomatology may develop after COVID-19, irrespective of the acute disease severity, age, and comorbidities. Frail individuals have reduced physiological reserves and manifested a worse COVID-19 course, during the acute setting. However, it is still unknown, whether frailty may subtend some long COVID-19 manifestations. We explored the prevalence of long COVID-19 disturbs in COVID-19 survivals.
Methods UNASSIGNED
This was an observational study. Patients aged 65 years or older were followed-up 1, 3, and 6 months after hospitalization for COVID-19 pneumonia.
Results UNASSIGNED
A total of 382 patients were enrolled. Frail patients were more malnourished (median Mini Nutritional Assessment Short Form score 8 vs. 9,
Conclusion UNASSIGNED
The precocious identification of frail COVID-19 survivors, who manifest more motor and respiratory complaints during the follow-up, could improve the long-term management of these COVID-19 sequelae.

Identifiants

pubmed: 35911387
doi: 10.3389/fmed.2022.834887
pmc: PMC9329529
doi:

Types de publication

Journal Article

Langues

eng

Pagination

834887

Informations de copyright

Copyright © 2022 Damanti, Cilla, Cilona, Fici, Merolla, Pacioni, De Lorenzo, Martinenghi, Vitali, Magnaghi, Fumagalli, Gennaro Mazza, Benedetti, Tresoldi and Rovere Querini.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Références

Arch Intern Med. 1995 May 22;155(10):1060-4
pubmed: 7748049
Psychoneuroendocrinology. 2019 Aug;106:293-311
pubmed: 31154264
Lancet. 2021 Jan 16;397(10270):220-232
pubmed: 33428867
BMJ Open. 2021 Mar 30;11(3):e048391
pubmed: 33785495
Psychol Med. 1988 Nov;18(4):1007-19
pubmed: 3078045
JAMA Netw Open. 2020 Nov 2;3(11):e2029540
pubmed: 33211114
Nat Commun. 2015 Dec 15;6:10145
pubmed: 26666572
Nat Med. 2021 Apr;27(4):601-615
pubmed: 33753937
Arch Gerontol Geriatr. 2016 Jan-Feb;62:97-102
pubmed: 26323650
S Afr Med J. 2020 Nov 23;111(1):10-12
pubmed: 33403997
J Nutr Health Aging. 2020;24(9):928-937
pubmed: 33155617
Intensive Care Med. 2020 Aug;46(8):1634-1636
pubmed: 32451583
Lancet. 2013 Mar 2;381(9868):752-62
pubmed: 23395245
J Am Geriatr Soc. 2008 Dec;56(12):2171-9
pubmed: 19093915
J Am Med Dir Assoc. 2016 Aug 1;17(8):762-4
pubmed: 27349623
Heart. 2015 Nov;101(21):1738-47
pubmed: 26310262
JAMA Cardiol. 2020 Nov 01;5(11):1265-1273
pubmed: 32730619
J Nutr Health Aging. 2020;24(9):948-950
pubmed: 33155619
Infect Control Hosp Epidemiol. 2020 May;41(5):499-504
pubmed: 32146920
Nat Rev Cardiol. 2018 Sep;15(9):505-522
pubmed: 30065258
CMAJ. 1997 Oct 15;157(8):1081-4
pubmed: 9347779
N Engl J Med. 2020 Jul 9;383(2):120-128
pubmed: 32437596
Age Ageing. 2020 Jul 1;49(4):499-500
pubmed: 32374368
Lancet Public Health. 2020 Aug;5(8):e444-e451
pubmed: 32619408
Nutrients. 2019 Aug 23;11(9):
pubmed: 31443594
Curr Opin Psychiatry. 2019 Sep;32(5):381-387
pubmed: 31145144
Pragmat Obs Res. 2021 Aug 11;12:93-104
pubmed: 34408531
Clin Nutr. 2021 Aug 16;:
pubmed: 34465493
Aging Dis. 2020 Dec 1;11(6):1345-1351
pubmed: 33269092
Front Endocrinol (Lausanne). 2022 Feb 17;13:801133
pubmed: 35250860
J Infect Dis. 2020 Jul 6;222(3):428-437
pubmed: 32147711
J Gerontol A Biol Sci Med Sci. 2007 Jul;62(7):722-7
pubmed: 17634318
Sci Rep. 2021 Aug 5;11(1):15929
pubmed: 34354164
Diabetes Metab Syndr. 2021 Jan-Feb;15(1):145-146
pubmed: 33341598
Open Forum Infect Dis. 2020 Oct 21;7(12):ofaa509
pubmed: 33403218
EClinicalMedicine. 2021 Jan 07;31:100683
pubmed: 33490928
J Nutr Health Aging. 2020;24(7):699-704
pubmed: 32744564
JAMA. 2010 Nov 3;304(17):1919-28
pubmed: 21045098
J Nutr Health Aging. 2018;22(8):952-958
pubmed: 30272099
J Am Med Dir Assoc. 2019 Feb;20(2):152-158.e2
pubmed: 30270027
Acta Biomed. 2020 Jul 20;91(9-S):22-28
pubmed: 32701913
J Am Geriatr Soc. 2010 Apr;58(4):681-7
pubmed: 20345864
J Psychosom Res. 2019 May;120:66-73
pubmed: 30929710
Aging Dis. 2018 Feb 1;9(1):151-164
pubmed: 29392090
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Pharmacoeconomics. 2018 Jun;36(6):645-661
pubmed: 29572719
J Am Med Dir Assoc. 2013 Aug;14(8):531-2
pubmed: 23810110
Ageing Res Rev. 2017 Jul;36:1-10
pubmed: 28223244
Geriatr Gerontol Int. 2021 Jan;21(1):39-42
pubmed: 33202485
Panminerva Med. 2022 Jun;64(2):244-252
pubmed: 33073557
J Am Geriatr Soc. 2009 Sep;57(9):1660-5
pubmed: 19682121
PLoS One. 2014 Dec 04;9(12):e113637
pubmed: 25474696
J Gerontol A Biol Sci Med Sci. 2001 Jun;56(6):M366-72
pubmed: 11382797
Respir Physiol Neurobiol. 2016 Jun;226:137-46
pubmed: 26467183
J Hosp Med. 2014 May;9(5):277-82
pubmed: 24616216
BMC Geriatr. 2008 Sep 30;8:24
pubmed: 18826625
Chest. 2018 Apr;153(4):1040-1051
pubmed: 28887062
Brain Behav Immun. 2010 Oct;24(7):1209-17
pubmed: 20447453
N Engl J Med. 1995 Mar 2;332(9):556-61
pubmed: 7838189
MMWR Morb Mortal Wkly Rep. 2020 Jul 31;69(30):993-998
pubmed: 32730238
Expert Rev Clin Immunol. 2020 May;16(5):465-470
pubmed: 32237901

Auteurs

Sarah Damanti (S)

Unit of General Medicine and Advanced Care, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Institute, Milan, Italy.

Marta Cilla (M)

Unit of General Medicine and Advanced Care, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Institute, Milan, Italy.

Maria Cilona (M)

Faculty of Medicine and Surgery, Vita-Salute San Raffaele University, Milan, Italy.

Aldo Fici (A)

Faculty of Medicine and Surgery, Vita-Salute San Raffaele University, Milan, Italy.

Aurora Merolla (A)

Faculty of Medicine and Surgery, Vita-Salute San Raffaele University, Milan, Italy.

Giacomo Pacioni (G)

Faculty of Medicine and Surgery, Vita-Salute San Raffaele University, Milan, Italy.

Rebecca De Lorenzo (R)

Faculty of Medicine and Surgery, Vita-Salute San Raffaele University, Milan, Italy.

Sabina Martinenghi (S)

San Raffaele Diabetes Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.

Giordano Vitali (G)

San Raffaele Diabetes Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.

Cristiano Magnaghi (C)

Department of Immunology, Transplantation and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy.

Anna Fumagalli (A)

COVID Trial Unit, Department of Internal Medicine, IRCCS San Raffaele Institute, Milan, Italy.

Mario Gennaro Mazza (M)

Faculty of Medicine and Surgery, Vita-Salute San Raffaele University, Milan, Italy.
Psychiatry & Clinical Psychobiology, Division of Neuroscience, IRCCS Scientific Institute Ospedale San Raffaele, Milan, Italy.

Francesco Benedetti (F)

Faculty of Medicine and Surgery, Vita-Salute San Raffaele University, Milan, Italy.
Psychiatry & Clinical Psychobiology, Division of Neuroscience, IRCCS Scientific Institute Ospedale San Raffaele, Milan, Italy.

Moreno Tresoldi (M)

Unit of General Medicine and Advanced Care, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Institute, Milan, Italy.

Patrizia Rovere Querini (P)

Faculty of Medicine and Surgery, Vita-Salute San Raffaele University, Milan, Italy.
Department of Immunology, Transplantation and Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy.

Classifications MeSH