Melanoma central nervous system metastases: An update to approaches, challenges, and opportunities.
Journal
Pigment cell & melanoma research
ISSN: 1755-148X
Titre abrégé: Pigment Cell Melanoma Res
Pays: England
ID NLM: 101318927
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
received:
30
05
2022
accepted:
29
07
2022
pubmed:
2
8
2022
medline:
29
10
2022
entrez:
1
8
2022
Statut:
ppublish
Résumé
Brain metastases are the most common brain malignancy. This review discusses the studies presented at the third annual meeting of the Melanoma Research Foundation in the context of other recent reports on the biology and treatment of melanoma brain metastases (MBM). Although symptomatic MBM patients were historically excluded from immunotherapy trials, efforts from clinicians and patient advocates have resulted in more inclusive and even dedicated clinical trials for MBM patients. The results of checkpoint inhibitor trials were discussed in conversation with current standards of care for MBM patients, including steroids, radiotherapy, and targeted therapy. Advances in the basic scientific understanding of MBM, including the role of astrocytes and metabolic adaptations to the brain microenvironment, are exposing new vulnerabilities which could be exploited for therapeutic purposes. Technical advances including single-cell omics and multiplex imaging are expanding our understanding of the MBM ecosystem and its response to therapy. This unprecedented level of spatial and temporal resolution is expected to dramatically advance the field in the coming years and render novel treatment approaches that might improve MBM patient outcomes.
Identifiants
pubmed: 35912544
doi: 10.1111/pcmr.13059
pmc: PMC10171356
mid: NIHMS1893659
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Intramural
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
554-572Subventions
Organisme : NCI NIH HHS
ID : R01 CA227156
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA225450
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA245499
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA051008
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA263001
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA244975
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA221703
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA236034
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA252634
Pays : United States
Organisme : NINDS NIH HHS
ID : K12 NS080223
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA166376
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA196530
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA256289
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA211687
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA241490
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA121118
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA191489
Pays : United States
Informations de copyright
© 2022 The Authors. Pigment Cell & Melanoma Research published by John Wiley & Sons Ltd.
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