Association Between Cognition, Health Related Quality of Life, and Costs in a Population at Risk for Cognitive Decline.

Activities of Daily Living / psychology Cognition Cognitive Dysfunction / epidemiology Humans Quality of Life / psychology Risk Factors
At-risk HRQoL utilities care costs cognition, cognitive decline dementia, sf-6d

Journal

Journal of Alzheimer's disease : JAD
ISSN: 1875-8908
Titre abrégé: J Alzheimers Dis
Pays: Netherlands
ID NLM: 9814863

Informations de publication

Date de publication:
2022
Historique:
pubmed: 2 8 2022
medline: 21 9 2022
entrez: 1 8 2022
Statut: ppublish

Résumé

The association between health-related quality of life (HRQoL) and care costs in people at risk for cognitive decline is not well understood. Studying this association could reveal the potential benefits of increasing HRQoL and reducing care costs by improving cognition. In this exploratory data analysis we investigated the association between cognition, HRQoL utilities and costs in a well-functioning population at risk for cognitive decline. An exploratory data analysis was conducted using longitudinal 2-year data from the FINGER study (n = 1,120). A change score analysis was applied using HRQoL utilities and total medical care costs as outcome. HRQoL utilities were derived from the Short Form Health Survey-36 (SF-36). Total care costs comprised visits to a general practitioner, medical specialist, nurse, and days at hospital. Analyses were adjusted for activities of daily living (ADL) and depressive symptoms. Although univariable analysis showed an association between cognition and HRQoL utilities, multivariable analysis showed no association between cognition, HRQoL utilities and total care costs. A one-unit increase in ADL limitations was associated with a -0.006 (p < 0.001) decrease in HRQoL utilities and a one-unit increase in depressive symptoms was associated with a -0.004 (p < 0.001) decrease in HRQoL utilities. The level of cognition in people at-risk for cognitive decline does not seem to be associated with HRQoL utilities. Future research should examine the level at which cognitive decline starts to affect HRQoL and care costs. Ideally, this would be done by means of cross-validation in populations with various stages of cognitive functioning and decline.

Sections du résumé

BACKGROUND
The association between health-related quality of life (HRQoL) and care costs in people at risk for cognitive decline is not well understood. Studying this association could reveal the potential benefits of increasing HRQoL and reducing care costs by improving cognition.
OBJECTIVE
In this exploratory data analysis we investigated the association between cognition, HRQoL utilities and costs in a well-functioning population at risk for cognitive decline.
METHODS
An exploratory data analysis was conducted using longitudinal 2-year data from the FINGER study (n = 1,120). A change score analysis was applied using HRQoL utilities and total medical care costs as outcome. HRQoL utilities were derived from the Short Form Health Survey-36 (SF-36). Total care costs comprised visits to a general practitioner, medical specialist, nurse, and days at hospital. Analyses were adjusted for activities of daily living (ADL) and depressive symptoms.
RESULTS
Although univariable analysis showed an association between cognition and HRQoL utilities, multivariable analysis showed no association between cognition, HRQoL utilities and total care costs. A one-unit increase in ADL limitations was associated with a -0.006 (p < 0.001) decrease in HRQoL utilities and a one-unit increase in depressive symptoms was associated with a -0.004 (p < 0.001) decrease in HRQoL utilities.
CONCLUSION
The level of cognition in people at-risk for cognitive decline does not seem to be associated with HRQoL utilities. Future research should examine the level at which cognitive decline starts to affect HRQoL and care costs. Ideally, this would be done by means of cross-validation in populations with various stages of cognitive functioning and decline.

Identifiants

DOI: 10.3233/JAD-215304 PMID: 35912737 PMC: PMC9535559
pubmed: 35912737
pii: JAD215304
doi: 10.3233/JAD-215304
pmc: PMC9535559
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

623-632

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Auteurs

Niels Janssen (N)

Department of Psychiatry and Neuropsychology, Alzheimer Centre Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.

Ron L Handels (RL)

Department of Psychiatry and Neuropsychology, Alzheimer Centre Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.
Department of Neurobiology, Care Science and Society, Division of Neurogeriatrics, Karolinska Institute, Stockholm, Sweden.

Anders Wimo (A)

Department of Neurobiology, Care Science and Society, Division of Neurogeriatrics, Karolinska Institute, Stockholm, Sweden.
Centre for Research & Development, Uppsala University/County Council of Gävleborg, Gävle, Sweden.

Riitta Antikainen (R)

Center for Life Course Health Research/Geriatrics, University of Oulu, Oulu, Finland.
Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.

Tiina Laatikainen (T)

Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Finland.
Joint Municipal Authority for North Karelia Social and Health Services (Siun sote), Finland.

Hilkka Soininen (H)

Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.
Department of Neurology, Kuopio University Hospital, Kuopio, Finland.

Timo Strandberg (T)

Institute of Health Sciences/Geriatrics, University of Oulu and Oulu University Hospital, Oulu, Finland.
Department of Medicine, Geriatric Clinic, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland.

Jaakko Tuomilehto (J)

Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Department of Public Health, University of Helsinki, Helsinki, Finland.
South Ostrobothnia Central Hospital, Seinajoki, Finland.
Saudi Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.

Miia Kivipelto (M)

Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.
Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden.
Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, UK.

Silvia M A A Evers (SMAA)

Department of Health Services Research, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands.
Trimbos Institute, Netherlands Institute of Mental Health and Addiction, Centre for Economic Evaluation Utrecht, Utrecht, The Netherlands.

Frans R J Verhey (FRJ)

Department of Psychiatry and Neuropsychology, Alzheimer Centre Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.

Tiia Ngandu (T)

Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden.

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Classifications MeSH

questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Réadaptation › Activités de la vie quotidienne › Association Between Cognition, Health Related...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Association Between Cognition, Health Related...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Association Between Cognition, Health Related...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Association Between Cognition, Health Related...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › Association Between Cognition, Health Related...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Association Between Cognition, Health Related...