The unmitigated profile of COVID-19 infectiousness.
COVID-19
SARS-CoV-2
computational biology
epidemiology
generation interval
global health
human
mitigation
systems biology
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
01 08 2022
01 08 2022
Historique:
received:
31
03
2022
accepted:
27
07
2022
pubmed:
2
8
2022
medline:
24
8
2022
entrez:
1
8
2022
Statut:
epublish
Résumé
Quantifying the temporal dynamics of infectiousness of individuals infected with SARS-CoV-2 is crucial for understanding the spread of COVID-19 and for evaluating the effectiveness of mitigation strategies. Many studies have estimated the infectiousness profile using observed serial intervals. However, statistical and epidemiological biases could lead to underestimation of the duration of infectiousness. We correct for these biases by curating data from the initial outbreak of the pandemic in China (when mitigation was minimal), and find that the infectiousness profile of the original strain is longer than previously thought. Sensitivity analysis shows our results are robust to model structure, assumed growth rate and potential observational biases. Although unmitigated transmission data is lacking for variants of concern (VOCs), previous analyses suggest that the alpha and delta variants have faster within-host kinetics, which we extrapolate to crude estimates of variant-specific unmitigated generation intervals. Knowing the unmitigated infectiousness profile of infected individuals can inform estimates of the effectiveness of isolation and quarantine measures. The framework presented here can help design better quarantine policies in early stages of future epidemics.
Identifiants
pubmed: 35913120
doi: 10.7554/eLife.79134
pii: 79134
pmc: PMC9391043
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CIHR
Pays : Canada
Informations de copyright
© 2022, Sender, Bar-On et al.
Déclaration de conflit d'intérêts
RS, YB, SP, EN, JD, RM No competing interests declared
Références
Lancet Infect Dis. 2022 Feb;22(2):183-195
pubmed: 34756186
Euro Surveill. 2021 Dec;26(50):
pubmed: 34915975
BMC Med. 2021 Apr 14;19(1):94
pubmed: 33849546
Lancet Public Health. 2021 Mar;6(3):e175-e183
pubmed: 33484644
J Infect Dis. 2022 Mar 2;225(5):793-799
pubmed: 34865022
Science. 2021 Jul 9;373(6551):
pubmed: 34035154
Euro Surveill. 2020 Jul;25(29):
pubmed: 32720639
Euro Surveill. 2020 Apr;25(17):
pubmed: 32372755
Proc Biol Sci. 2007 Feb 22;274(1609):599-604
pubmed: 17476782
Elife. 2021 Sep 27;10:
pubmed: 34569939
N Engl J Med. 2020 Mar 26;382(13):1199-1207
pubmed: 31995857
Infect Control Hosp Epidemiol. 2020 Jun;41(6):750-751
pubmed: 32146921
Lancet Infect Dis. 2022 May;22(5):603-610
pubmed: 35176230
Science. 2020 May 8;368(6491):
pubmed: 32234805
Science. 2020 Aug 28;369(6507):1106-1109
pubmed: 32694200
Science. 2021 Jan 15;371(6526):
pubmed: 33234698
Sci Transl Med. 2021 Apr 14;13(589):
pubmed: 33619080
Innovation (Camb). 2020 May 21;1(1):100001
pubmed: 33554183
Am J Epidemiol. 2003 Dec 1;158(11):1039-47
pubmed: 14630599
Nature. 2020 Aug;584(7820):257-261
pubmed: 32512579
Nat Methods. 2020 Mar;17(3):261-272
pubmed: 32015543
Nat Med. 2022 May;28(5):1031-1041
pubmed: 35361992
Lancet. 2020 Feb 29;395(10225):689-697
pubmed: 32014114
PLoS Comput Biol. 2020 Dec 10;16(12):e1008409
pubmed: 33301457
Clin Infect Dis. 2021 Dec 16;73(12):2344-2352
pubmed: 34117868
Nat Med. 2022 Jul;28(7):1491-1500
pubmed: 35395151
Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):
pubmed: 33361331
Elife. 2021 Apr 26;10:
pubmed: 33899740
Emerg Infect Dis. 2020 Jun;26(6):1341-1343
pubmed: 32191173
Lancet Infect Dis. 2020 Dec;20(12):1381-1389
pubmed: 32822577
Lancet Infect Dis. 2020 Jul;20(7):793-802
pubmed: 32247326
Emerg Infect Dis. 2022 Feb;28(2):407-410
pubmed: 34906289
Lancet Public Health. 2020 May;5(5):e289-e296
pubmed: 32330458
J Theor Biol. 2011 Sep 7;284(1):52-60
pubmed: 21704640
N Engl J Med. 2021 Dec 23;385(26):2489-2491
pubmed: 34941024
Clin Infect Dis. 2021 Jun 1;72(11):e921
pubmed: 32986798
Nat Med. 2020 May;26(5):672-675
pubmed: 32296168
Epidemiol Infect. 2020 Jun 19;148:e117
pubmed: 32594928
Lancet Reg Health Eur. 2022 Feb;13:100278
pubmed: 34849500
Ann Intern Med. 2020 May 05;172(9):577-582
pubmed: 32150748
Math Biosci. 2007 Jul;208(1):300-11
pubmed: 17174352
Emerg Infect Dis. 2020 Aug;26(8):1915-1917
pubmed: 32320641
Influenza Other Respir Viruses. 2021 Jan;15(1):19-26
pubmed: 32767657
Science. 2020 May 1;368(6490):493-497
pubmed: 32213647
Math Biosci. 2008 May;213(1):71-9
pubmed: 18394654
Emerg Infect Dis. 2020 Aug;26(8):1912-1914
pubmed: 32330410
Lancet. 2021 Sep 4;398(10303):837-838
pubmed: 34388398
Proc Biol Sci. 2015 Dec 22;282(1821):20152026
pubmed: 26674948
JAMA Intern Med. 2022 Jul 1;182(7):701-709
pubmed: 35486394
Nat Med. 2020 Apr;26(4):506-510
pubmed: 32284616
J R Soc Interface. 2020 Jul;17(168):20200144
pubmed: 32693748
JAMA. 2020 May 19;323(19):1915-1923
pubmed: 32275295
Science. 2020 Apr 24;368(6489):395-400
pubmed: 32144116