Effect Modification between Genes and Environment and Parkinson's Disease Risk.
Journal
Annals of neurology
ISSN: 1531-8249
Titre abrégé: Ann Neurol
Pays: United States
ID NLM: 7707449
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
revised:
26
07
2022
received:
07
03
2022
accepted:
28
07
2022
pubmed:
2
8
2022
medline:
26
10
2022
entrez:
1
8
2022
Statut:
ppublish
Résumé
Parkinson's disease (PD) is a complex neurodegenerative condition in which genetic and environmental factors interact to contribute to its etiology. Remarkable progress has been made in deciphering disease etiology through genetic approaches, but there is limited data about how environmental and genetic factors interact to modify penetrance, risk, and disease severity. Here, we provide insights into environmental modifiers of PD, discussing precedents from other neurological and non-neurological conditions. Based on these examples, we outline genetic and environmental factors contributing to PD and review potential environmental modifiers of penetrance and clinical variability in monogenic and idiopathic PD. We also highlight the potential challenges and propose how future studies might tackle these important questions. ANN NEUROL 2022;92:715-724.
Identifiants
pubmed: 35913124
doi: 10.1002/ana.26467
pmc: PMC9588606
mid: NIHMS1827195
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
715-724Subventions
Organisme : NIA NIH HHS
ID : K24 AG000949
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 AG000949
Pays : United States
Organisme : Intramural NIH HHS
ID : Z99 AG999999
Pays : United States
Informations de copyright
© 2022 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.
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