Platform for Active Vaccine Formulation Using a Two-Mode Enhancement Mechanism of Epitope Presentation by Pickering Emulsion.

Animals COVID-19 / prevention & control Emulsions Epitopes Immunoglobulin G Mice SARS-CoV-2 Vaccination Vaccines, Subunit
Pickering emulsion epitope-based vaccination plant virus subunit vaccines virus-like-particles

Journal

ACS applied bio materials
ISSN: 2576-6422
Titre abrégé: ACS Appl Bio Mater
Pays: United States
ID NLM: 101729147

Informations de publication

Date de publication:
15 08 2022
Historique:
pubmed: 2 8 2022
medline: 17 8 2022
entrez: 1 8 2022
Statut: ppublish

Résumé

The efficiency of epitope-based vaccination (subunit vaccines) is tightly correlated with heterogeneity and the high density of epitope presentation, which maximizes the potential antigenic determinants. Here, we developed a two-mode platform for intensifying the epitope presentation of subunit vaccines. The two-mode epitope presentation enhancement includes a covalent attachment of high concentrations of SARS-CoV-2-S1 peptide epitope to the surface of virus-like-particles (VLPs) and the subsequent assembly of VLP/epitope conjugates on the oil droplet surface at an oil/water interface of an emulsion as Pickering stabilizers. The resultant emulsions were stable for weeks in ambient conditions, and our platform was challenged using the epitope of the SARS-CoV-2-S1 peptide that served as a model epitope in this study.

Identifiants

DOI: 10.1021/acsabm.2c00410 PMID: 35913405 PMC: PMC9382630
pubmed: 35913405
doi: 10.1021/acsabm.2c00410
pmc: PMC9382630
doi:

Substances chimiques

Emulsions 0
Epitopes 0
Immunoglobulin G 0
Vaccines, Subunit 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3859-3869

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Auteurs

Guy Mechrez (G)

Department of Food Science, Institute of Postharvest and Food Science, Agricultural Research Organization, The Volcani Institute, Rishon LeZion 7505101, Israel.

Karthik Ananth Mani (KA)

Department of Food Science, Institute of Postharvest and Food Science, Agricultural Research Organization, The Volcani Institute, Rishon LeZion 7505101, Israel.
Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 7610001, Israel.

Abhijit Saha (A)

Institute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel.
Department of Chemistry, SRM Institute of Science and Technology, Kattankulathur, Chennai 603203, India.

Oded Lachman (O)

Department of Plant Pathology and Weed Research, Institute of Plant Protection, Agricultural Research Organization, The Volcani Institute, Rishon LeZion 7505101, Israel.

Neta Luria (N)

Department of Plant Pathology and Weed Research, Institute of Plant Protection, Agricultural Research Organization, The Volcani Institute, Rishon LeZion 7505101, Israel.

Ori Molad (O)

Institute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel.
Department of Plant Pathology and Weed Research, Institute of Plant Protection, Agricultural Research Organization, The Volcani Institute, Rishon LeZion 7505101, Israel.

Liliya Kotliarevski (L)

Department of Food Science, Institute of Postharvest and Food Science, Agricultural Research Organization, The Volcani Institute, Rishon LeZion 7505101, Israel.
Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 7610001, Israel.

Einat Zelinger (E)

The Interdepartmental Equipment Unit, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 7610001, Israel.

Elisheva Smith (E)

Department of Plant Pathology and Weed Research, Institute of Plant Protection, Agricultural Research Organization, The Volcani Institute, Rishon LeZion 7505101, Israel.

Noga Yaakov (N)

Department of Food Science, Institute of Postharvest and Food Science, Agricultural Research Organization, The Volcani Institute, Rishon LeZion 7505101, Israel.

Dalia Shabashov Stone (DS)

Pharmaseed Ltd., Ness Ziona 74047, Israel.

Meital Reches (M)

Institute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel.
ORCID: 0000-0001-5652-9868

Aviv Dombrovsky (A)

Department of Plant Pathology and Weed Research, Institute of Plant Protection, Agricultural Research Organization, The Volcani Institute, Rishon LeZion 7505101, Israel.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Platform for Active Vaccine Formulation Using...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Platform for Active Vaccine Formulation Using...
questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Émulsions › Platform for Active Vaccine Formulation Using...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › Platform for Active Vaccine Formulation Using...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline G › Platform for Active Vaccine Formulation Using...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Platform for Active Vaccine Formulation Using...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Platform for Active Vaccine Formulation Using...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Prévention primaire › Immunisation › Vaccination › Platform for Active Vaccine Formulation Using...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins sous-unitaires › Platform for Active Vaccine Formulation Using...