Studies on the partial characterization of extracted glycosaminoglycans from fish waste and its potentiality in modulating obesity through in-vitro and in-vivo.
3T3L1 pre-adipocytes
Anti-obesity
Bile acid binding
C57BL/6 mice
Fish waste
Glycosaminoglycans
Journal
Glycoconjugate journal
ISSN: 1573-4986
Titre abrégé: Glycoconj J
Pays: United States
ID NLM: 8603310
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
29
03
2022
accepted:
19
07
2022
revised:
14
07
2022
pubmed:
2
8
2022
medline:
16
8
2022
entrez:
1
8
2022
Statut:
ppublish
Résumé
Glycosaminoglycans (GAGs) are bioactive polysaccharides or glycoconjugates found in the fish waste having significant health impacts. In the present study it has been attempted to extract GAGs from mackerel fish waste through chemical and enzymatic methods. Further, the extracted GAGs (e-GAGs) were analyzed for their composition (uronic acid, total sugar & sulfate), chemical characterization was carried out through techniques of scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) & Proton NMR. Further, probable major GAGs present was identified by enzymatic digestion. The biological potential of the extracted glycoconjugate was assessed further through in-vitro and in-vivo studies. In-vitro biological activity showed good lipase inhibition (IC
Identifiants
pubmed: 35913650
doi: 10.1007/s10719-022-10077-5
pii: 10.1007/s10719-022-10077-5
doi:
Substances chimiques
Bile Acids and Salts
0
Glycosaminoglycans
0
Triglycerides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
525-542Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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