Hypergravity load-induced hyperglycemia occurs due to hypothermia and increased plasma corticosterone level in mice.
Adrenaline
Gravity
Noradrenaline
Vestibular system
Journal
The journal of physiological sciences : JPS
ISSN: 1880-6562
Titre abrégé: J Physiol Sci
Pays: Japan
ID NLM: 101262417
Informations de publication
Date de publication:
01 Aug 2022
01 Aug 2022
Historique:
received:
19
05
2022
accepted:
18
07
2022
entrez:
1
8
2022
pubmed:
2
8
2022
medline:
4
8
2022
Statut:
epublish
Résumé
Hypothermia has been observed during hypergravity load in mice and rats. This response is beneficial for maintaining blood glucose level, although food intake decreases. However, saving glucose is not enough to maintain blood glucose level during hypergravity load. In this study, we examined the contribution of humoral factors related to glycolysis in maintaining blood glucose level in a 2 G environment. Increased plasma corticosterone levels were observed in mice with intact peripheral vestibular organs, but not in mice with vestibular lesions. Plasma glucagon levels did not change, and decrease in plasma adrenaline levels was observed in mice with intact peripheral vestibular organs. Accordingly, it is possible that increase in plasma corticosterone level and hypothermia contribute to prevent hypoglycemia in a 2 G environment.
Identifiants
pubmed: 35915429
doi: 10.1186/s12576-022-00844-2
pii: 10.1186/s12576-022-00844-2
pmc: PMC10717132
doi:
Substances chimiques
Blood Glucose
0
Corticosterone
W980KJ009P
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
18Subventions
Organisme : Japan Society for the Promotion of Science
ID : 19K07283
Organisme : Japan Society for the Promotion of Science
ID : 18K06850
Informations de copyright
© 2022. The Author(s).
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