In Silico and In Vitro Approach to Assess Direct Allosteric AMPK Activators from Nature.

AMP-Activated Protein Kinases / metabolism

Journal

Planta medica
ISSN: 1439-0221
Titre abrégé: Planta Med
Pays: Germany
ID NLM: 0066751

Informations de publication

Date de publication:
Aug 2022
Historique:
entrez: 2 8 2022
pubmed: 3 8 2022
medline: 4 8 2022
Statut: ppublish

Résumé

The 5'-adenosine monophosphate-activated protein kinase (AMPK) is an important metabolic regulator. Its allosteric drug and metabolite binding (ADaM) site was identified as an attractive target for direct AMPK activation and holds promise as a novel mechanism for the treatment of metabolic diseases. With the exception of lusianthridin and salicylic acid, no natural product (NP) is reported so far to directly target the ADaM site. For the streamlined assessment of direct AMPK activators from the pool of NPs, an integrated workflow using

Identifiants

DOI: 10.1055/a-1797-3030 PMID: 35915889
pubmed: 35915889
doi: 10.1055/a-1797-3030
doi:

Substances chimiques

AMP-Activated Protein Kinases EC 2.7.11.31

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

794-804

Subventions

Organisme : P29392
ID : Austrian Science Fund
Organisme : P34028
ID : Austrian Science Fund

Informations de copyright

Thieme. All rights reserved.

Déclaration de conflit d'intérêts

The authors declare that they have no conflict of interest.

Auteurs

Benjamin Kirchweger (B)

Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria.
Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences (PhaNuSpo), University of Vienna, Vienna, Austria.

Andreas Wasilewicz (A)

Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria.
Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences (PhaNuSpo), University of Vienna, Vienna, Austria.

Katrin Fischhuber (K)

Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria.

Ammar Tahir (A)

Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria.

Ya Chen (Y)

Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria.

Elke H Heiss (EH)

Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria.

Thierry Langer (T)

Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria.

Johannes Kirchmair (J)

Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria.

Judith M Rollinger (JM)

Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria.
ORCID: 0000-0001-6581-0774

Articles similaires

Polyoxometalates Ameliorate Metabolic Dysfunction-Associated Steatotic Liver Disease by Activating the AMPK Signaling Pathway.

Dandan Wang, Jingguo Wang, Zequn Yin et al.
1.00
Animals Signal Transduction AMP-Activated Protein Kinases Mice Tungsten Compounds

β-catenin-inhibited Sumoylation modification of LKB1 and fatty acid metabolism is critical in renal fibrosis.

Shuangqin Chen, Jiemei Li, Ye Liang et al.
1.00
Sumoylation Animals beta Catenin Fibrosis Humans

AdipoRon Alleviates Liver Injury by Protecting Hepatocytes from Mitochondrial Damage Caused by Ionizing Radiation.

Yi Liu, Yinfen Xu, Huilin Ji et al.
1.00
Animals Hepatocytes Receptors, Adiponectin Mice Radiation, Ionizing

Loureirin B Reduces Insulin Resistance and Chronic Inflammation in a Rat Model of Polycystic Ovary Syndrome by Upregulating GPR120 and Activating the LKB1/AMPK Signaling Pathway.

Jing Wang, Zheng Huang, Zhiyong Cao et al.
1.00
Animals Female Polycystic Ovary Syndrome Rats Insulin Resistance

Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › AMP-Activated Protein Kinases › In Silico and In Vitro Approach to Assess...