Assessing mild cognitive impairment using object-location memory in immersive virtual environments.
Alzheimer's disease
entorhinal cortex
spatial cognition
virtual reality
Journal
Hippocampus
ISSN: 1098-1063
Titre abrégé: Hippocampus
Pays: United States
ID NLM: 9108167
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
revised:
24
06
2022
received:
07
02
2022
accepted:
16
07
2022
pubmed:
3
8
2022
medline:
20
8
2022
entrez:
2
8
2022
Statut:
ppublish
Résumé
Pathological changes in the medial temporal lobe (MTL) are found in the early stages of Alzheimer's disease (AD) and aging. The earliest pathological accumulation of tau colocalizes with the areas of the MTL involved in object processing as part of a wider anterolateral network. Here, we sought to assess the diagnostic potential of memory for object locations in iVR environments in individuals at high risk of AD dementia (amnestic mild cognitive impairment [aMCI] n = 23) as compared to age-related cognitive decline. Consistent with our primary hypothesis that early AD would be associated with impaired object location, aMCI patients exhibited impaired spatial feature binding. Compared to both older (n = 24) and younger (n = 53) controls, aMCI patients, recalled object locations with significantly less accuracy (p < .001), with a trend toward an impaired identification of the object's correct context (p = .05). Importantly, these findings were not explained by deficits in object recognition (p = .6). These deficits differentiated aMCI from controls with greater accuracy (AUC = 0.89) than the standard neuropsychological tests. Within the aMCI group, 16 had CSF biomarkers indicative of their likely AD status (MCI+ n = 9 vs. MCI- n = 7). MCI+ showed lower accuracy in the object-context association than MCI- (p = .03) suggesting a selective deficit in object-context binding postulated to be associated with anterior-temporal areas. MRI volumetric analysis across healthy older participants and aMCI revealed that test performance positively correlates with lateral entorhinal cortex volumes (p < .05) and hippocampus volumes (p < .01), consistent with their hypothesized role in binding contextual and spatial information with object identity. Our results indicate that tests relying on the anterolateral object processing stream, and in particular requiring successful binding of an object with spatial information, may aid detection of pre-dementia AD due to the underlying early spread of tau pathology.
Identifiants
pubmed: 35916343
doi: 10.1002/hipo.23458
pmc: PMC9543035
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
660-678Subventions
Organisme : Wellcome Trust
ID : 202805/Z/16/Z
Pays : United Kingdom
Informations de copyright
© 2022 The Authors. Hippocampus published by Wiley Periodicals LLC.
Références
Psychol Aging. 2015 Mar;30(1):26-35
pubmed: 25528066
Trends Cogn Sci. 2007 Sep;11(9):379-86
pubmed: 17707683
Acta Neuropathol. 2011 May;121(5):589-95
pubmed: 21516512
Nat Rev Neurosci. 2008 Mar;9(3):182-94
pubmed: 18270514
Elife. 2019 Sep 02;8:
pubmed: 31475904
J Neurosci. 2019 Oct 30;39(44):8788-8797
pubmed: 31541019
Neurology. 2000 Dec 12;55(11):1613-20
pubmed: 11113213
Neuropsychologia. 2007 Oct 1;45(13):2963-74
pubmed: 17658561
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
PLoS One. 2012;7(10):e48214
pubmed: 23118956
Learn Mem. 2008 Oct 02;15(10):785-91
pubmed: 18832565
Curr Alzheimer Res. 2018;15(3):229-236
pubmed: 29086696
Neurobiol Learn Mem. 2016 Sep;133:118-128
pubmed: 27330015
Cortex. 2016 May;78:150-164
pubmed: 27085491
Neuropsychologia. 2013 Oct;51(12):2442-9
pubmed: 23313292
J Neurosci. 2016 Mar 2;36(9):2555-7
pubmed: 26936996
Nat Neurosci. 2019 Dec;22(12):2078-2086
pubmed: 31712776
J Intern Med. 2004 Sep;256(3):183-94
pubmed: 15324362
J Comp Neurol. 2015 Oct 15;523(15):2233-53
pubmed: 25872498
J Cogn Neurosci. 2019 May;31(5):711-729
pubmed: 30822207
J Alzheimers Dis. 2016 Mar 26;52(2):573-80
pubmed: 27031465
Hippocampus. 2013 May;23(5):352-66
pubmed: 23389958
Neuron. 2014 Mar 5;81(5):1165-1178
pubmed: 24607234
Brain. 2012 Dec;135(Pt 12):3757-69
pubmed: 23250887
Lancet Neurol. 2007 Aug;6(8):734-46
pubmed: 17616482
Brain. 2019 Aug 1;142(8):2492-2509
pubmed: 31199481
Acta Neuropathol. 2011 Feb;121(2):171-81
pubmed: 21170538
Ageing Res Rev. 2013 Jan;12(1):201-13
pubmed: 22771718
Neuroscience. 2003;119(2):577-88
pubmed: 12770570
Neuroimage. 2015 Jul 15;115:117-37
pubmed: 25936807
Sci Rep. 2016 Jan 13;6:19203
pubmed: 26758902
Hippocampus. 2010 Nov;20(11):1263-90
pubmed: 20928833
J Clin Neuropsychol. 1984 Nov;6(4):433-40
pubmed: 6501581
Brain. 2010 Sep;133(9):2702-13
pubmed: 20624814
Neuropsychologia. 2012 Nov;50(13):3062-9
pubmed: 22846335
Neurobiol Aging. 2012 Jan;33(1):202.e15-22
pubmed: 20832911
Ann Neurol. 2009 Apr;65(4):403-13
pubmed: 19296504
Hippocampus. 2019 Oct;29(10):971-979
pubmed: 31070289
Cereb Cortex. 2013 Feb;23(2):451-9
pubmed: 22357665
Science. 2015 Oct 23;350(6259):430-3
pubmed: 26494756
Hippocampus. 2007;17(1):34-48
pubmed: 17143905
Nat Neurosci. 2017 Feb;20(2):173-175
pubmed: 27991898
Learn Mem. 2009 Dec 22;17(1):5-11
pubmed: 20028732
Neurosci Biobehav Rev. 2012 Aug;36(7):1597-608
pubmed: 21810443
J Cogn Neurosci. 2011 Oct;23(10):3052-67
pubmed: 21391761
Neuroimage. 2015 Nov 1;121:78-90
pubmed: 26209802
Cortex. 2020 Jul;128:61-72
pubmed: 32320848
Handb Clin Neurol. 2020;175:261-273
pubmed: 33008530
Sci Adv. 2018 Aug 22;4(8):eaar2768
pubmed: 30140737
Curr Biol. 2018 Apr 2;28(7):1108-1115.e6
pubmed: 29551413
Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5915-20
pubmed: 18408152
Neurobiol Aging. 2018 May;65:86-97
pubmed: 29454154
Front Syst Neurosci. 2017 May 17;11:30
pubmed: 28567006
Hum Brain Mapp. 2018 Jun;39(6):2500-2513
pubmed: 29468773
Nat Neurosci. 2014 Feb;17(2):304-11
pubmed: 24362760
Nat Rev Neurosci. 2012 Oct;13(10):713-26
pubmed: 22992647
Curr Biol. 2013 Mar 4;23(5):399-405
pubmed: 23434282
Brain. 2019 Jun 1;142(6):1751-1766
pubmed: 31121601
Hippocampus. 2022 Sep;32(9):660-678
pubmed: 35916343
Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):E4264-73
pubmed: 25246569
Neuron. 2018 Mar 7;97(5):1187-1198.e4
pubmed: 29518359
Science. 1998 May 8;280(5365):921-4
pubmed: 9572740
J Clin Exp Neuropsychol. 2006 Nov;28(8):1408-22
pubmed: 17050267
PLoS One. 2013;8(2):e57030
pubmed: 23468906
Alzheimers Dement (Amst). 2017 Nov 11;10:76-85
pubmed: 29255787
Br J Psychol. 2016 Feb;107(1):72-94
pubmed: 26756717
J Neurosci. 2017 May 31;37(22):5527-5538
pubmed: 28473640
Hippocampus. 2013 Dec;23(12):1280-90
pubmed: 23836525
Hippocampus. 2012 Oct;22(10):2045-58
pubmed: 22987681
Front Aging Neurosci. 2017 May 10;9:122
pubmed: 28539883
Brain. 2021 Oct 22;144(9):2771-2783
pubmed: 33725124
J Neurosci. 2018 Jan 17;38(3):530-543
pubmed: 29192126
EXCLI J. 2021 Sep 27;20:1458-1473
pubmed: 34737688
Hippocampus. 2016 May;26(5):633-45
pubmed: 26501829
JAMA Neurol. 2020 May 1;77(5):632-642
pubmed: 32091549
Brain Neurosci Adv. 2020 Jul 14;4:2398212820939463
pubmed: 32954005
Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2652-7
pubmed: 20133798
Front Hum Neurosci. 2018 Jun 21;12:250
pubmed: 29977198
Neurobiol Aging. 1997 Jul-Aug;18(4):351-7
pubmed: 9330961
Proc Natl Acad Sci U S A. 2006 May 23;103(21):8239-44
pubmed: 16702554
Elife. 2015 Jun 08;4:
pubmed: 26052749
Neurobiol Aging. 2020 Mar;87:132-137
pubmed: 31952867
Neuron. 2006 Nov 9;52(3):547-56
pubmed: 17088219
Neurobiol Aging. 2022 Apr;112:151-160
pubmed: 35182842
J Intern Med. 2004 Sep;256(3):195-204
pubmed: 15324363
PLoS One. 2012;7(8):e43620
pubmed: 22912894
Acta Neuropathol. 2014 Dec;128(6):755-66
pubmed: 25348064
Neuroimage Clin. 2017 May 26;15:466-482
pubmed: 28652965
Front Mol Neurosci. 2020 Oct 22;13:527543
pubmed: 33192287
Science. 2018 Nov 23;362(6417):945-949
pubmed: 30467169
J Neurol Neurosurg Psychiatry. 2011 Jan;82(1):58-66
pubmed: 20639384
Dement Geriatr Cogn Dis Extra. 2017 Mar 20;7(1):74-86
pubmed: 28611821
Philos Trans R Soc Lond B Biol Sci. 2013 Dec 23;369(1635):20130369
pubmed: 24366146
Front Hum Neurosci. 2015 Aug 03;9:431
pubmed: 26283949
Neurology. 2021 Mar 9;96(10):e1470-e1481
pubmed: 33408146
Elife. 2015 Jun 08;4:
pubmed: 26052748
Hippocampus. 2010 Nov;20(11):1245-62
pubmed: 20882548
Prog Brain Res. 2015;219:45-64
pubmed: 26072233
Front Behav Neurosci. 2011 Oct 28;5:69
pubmed: 22065409
J Neurosci. 2016 Mar 30;36(13):3660-75
pubmed: 27030753
J Neurosci. 2013 May 29;33(22):9246-58
pubmed: 23719794
Brain. 2009 Apr;132(Pt 4):1057-66
pubmed: 19293236
Brain Commun. 2020;2(1):fcaa025
pubmed: 32337508
Neuron. 2002 Jan 31;33(3):341-55
pubmed: 11832223
Exp Brain Res. 2016 Sep;234(9):2687-96
pubmed: 27180248
Neuroimage. 2020 Apr 15;210:116563
pubmed: 31972281
Hippocampus. 2018 Sep;28(9):680-687
pubmed: 28609014
Neuroimage. 2006 Jul 1;31(3):1116-28
pubmed: 16545965
J Cogn Neurosci. 1998 Jan;10(1):61-76
pubmed: 9526083
J Int Neuropsychol Soc. 2019 Aug;25(7):688-698
pubmed: 31111810
Alzheimers Dement (Amst). 2018 Nov 02;10:782-790
pubmed: 30555890
Neurobiol Aging. 2018 Apr;64:107-115
pubmed: 29358117
Alzheimers Dement. 2011 May;7(3):263-9
pubmed: 21514250
Clin Chem. 2010 Feb;56(2):248-53
pubmed: 19833838
Gen Hosp Psychiatry. 2019 Jan - Feb;56:13-18
pubmed: 30508772
Neuron. 2012 Feb 23;73(4):685-97
pubmed: 22365544
Curr Biol. 2013 Sep 9;23(17):1685-90
pubmed: 23954431
Hippocampus. 2013 May;23(5):380-91
pubmed: 23436324
Neuron. 2015 Oct 7;88(1):64-77
pubmed: 26447573
Neuropsychologia. 2011 Feb;49(3):518-27
pubmed: 21185847
Nat Neurosci. 2014 Nov;17(11):1598-606
pubmed: 25282616
J Int Neuropsychol Soc. 2010 Jan;16(1):200-4
pubmed: 19883520