Focal seizures are organized by feedback between neural activity and ion concentration changes.
computational biology
computational model
epilepsy
focal seizure
ion concentrations
none
systems biology
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
02 08 2022
02 08 2022
Historique:
received:
18
03
2021
accepted:
12
07
2022
pubmed:
3
8
2022
medline:
18
8
2022
entrez:
2
8
2022
Statut:
epublish
Résumé
Human and animal EEG data demonstrate that focal seizures start with low-voltage fast activity, evolve into rhythmic burst discharges and are followed by a period of suppressed background activity. This suggests that processes with dynamics in the range of tens of seconds govern focal seizure evolution. We investigate the processes associated with seizure dynamics by complementing the Hodgkin-Huxley mathematical model with the physical laws that dictate ion movement and maintain ionic gradients. Our biophysically realistic computational model closely replicates the electrographic pattern of a typical human focal seizure characterized by low voltage fast activity onset, tonic phase, clonic phase and postictal suppression. Our study demonstrates, for the first time in silico, the potential mechanism of seizure initiation by inhibitory interneurons via the initial build-up of extracellular K
Identifiants
pubmed: 35916367
doi: 10.7554/eLife.68541
pii: 68541
pmc: PMC9377802
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2022, Gentiletti et al.
Déclaration de conflit d'intérêts
DG, Md, VG, PS No competing interests declared
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