Molecular insights into peroxisome homeostasis and peroxisome biogenesis disorders.
Catalase
Organelle communication
Oxidative cell stress
Peroxisome biogenesis disorders
Peroxisome division machinery
Peroxisome homeostasis
Peroxisome-deficiency pathogenesis
Plasmalogen
Journal
Biochimica et biophysica acta. Molecular cell research
ISSN: 1879-2596
Titre abrégé: Biochim Biophys Acta Mol Cell Res
Pays: Netherlands
ID NLM: 101731731
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
received:
18
02
2022
revised:
25
07
2022
accepted:
27
07
2022
pubmed:
3
8
2022
medline:
9
9
2022
entrez:
2
8
2022
Statut:
ppublish
Résumé
Peroxisomes are single-membrane organelles essential for cell metabolism including the β-oxidation of fatty acids, synthesis of etherlipid plasmalogens, and redox homeostasis. Investigations into peroxisome biogenesis and the human peroxisome biogenesis disorders (PBDs) have identified 14 PEX genes encoding peroxins involved in peroxisome biogenesis and the mutation of PEX genes is responsible for the PBDs. Many recent findings have further advanced our understanding of the biology, physiology, and consequences of a functional deficit of peroxisomes. In this Review, we discuss cell defense mechanisms that counteract oxidative stress by 1) a proapoptotic Bcl-2 factor BAK-mediated release to the cytosol of H
Identifiants
pubmed: 35917894
pii: S0167-4889(22)00122-7
doi: 10.1016/j.bbamcr.2022.119330
pii:
doi:
Substances chimiques
Hydrogen Peroxide
BBX060AN9V
Catalase
EC 1.11.1.6
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
119330Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.