Key difference between transition state stabilization and ground state destabilization: increasing atomic charge densities before or during enzyme-substrate binding.
Journal
Chemical science
ISSN: 2041-6520
Titre abrégé: Chem Sci
Pays: England
ID NLM: 101545951
Informations de publication
Date de publication:
13 Jul 2022
13 Jul 2022
Historique:
received:
07
04
2022
accepted:
20
06
2022
entrez:
3
8
2022
pubmed:
4
8
2022
medline:
4
8
2022
Statut:
epublish
Résumé
The origin of the enormous catalytic power of enzymes has been extensively studied through experimental and computational approaches. Although precise mechanisms are still subject to much debate, enzymes are thought to catalyze reactions by stabilizing transition states (TSs) or destabilizing ground states (GSs). By exploring the catalysis of various types of enzyme-substrate noncovalent interactions, we found that catalysis by TS stabilization and the catalysis by GS destabilization share common features by reducing the free energy barriers (Δ
Identifiants
pubmed: 35919436
doi: 10.1039/d2sc01994a
pii: d2sc01994a
pmc: PMC9278421
doi:
Types de publication
Journal Article
Langues
eng
Pagination
8193-8202Subventions
Organisme : NIAID NIH HHS
ID : U01 AI124290
Pays : United States
Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
The authors declare no competing financial interests.
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