Effects of Red Rice Bran Extract on High-Fat Diet-Induced Obesity and Insulin Resistance in Mice.
hyperglycemia
hyperinsulinemia
insulin resistance
obesity
red rice bran
Journal
Preventive nutrition and food science
ISSN: 2287-1098
Titre abrégé: Prev Nutr Food Sci
Pays: Korea (South)
ID NLM: 101586663
Informations de publication
Date de publication:
30 Jun 2022
30 Jun 2022
Historique:
received:
16
11
2021
revised:
05
01
2022
accepted:
23
02
2022
entrez:
3
8
2022
pubmed:
4
8
2022
medline:
4
8
2022
Statut:
ppublish
Résumé
Insulin resistance is a salient player in the pathogenesis of obesity and its related abnormal glucose-insulin homeostasis. Red rice bran extract (RRBE) demonstrates several bioactive phytochemicals with anti-diabetic properties. However, little is known about its molecular mechanisms. Therefore, the present study was designed to investigate the anti-insulin resistant mechanisms of RRBE in a model of high-fat diet (HFD)-induced insulin resistance. In this study, mice were randomly divided into four groups: low-fat diet with distilled water (Group L), HFD with distilled water (Group H), HFD with 0.5 g/kg RRBE, and HFD with 1 g/kg RRBE. Metabolic parameters, histological changes in the pancreas, and gene expression levels were evaluated after treating HFD-fed mice with RRBE for six weeks. Mice from Group H exhib-ited significantly higher blood glucose levels prior to and after an oral glucose tolerance test, fasting serum insulin levels, islet size, pancreatic insulin expression levels, and lower skeletal muscle insulin-degrading enzyme (IDE) expression levels compared to Group L. In contrast, these were all significantly restored in the RRBE-treated groups. Also, RRBE treatment was found to upregulate the expression of insulin receptor substrate (IRS) and glucose transporter (GLUT) genes in the adipose tissues and GLUT genes in the muscles and livers of HFD-fed mice. According to our results, RRBE may ameliorate abnormal glucose-insulin metabolism by modulating the expression of insulin, IDE, IRS, and GLUT genes in the major metabolic target tissues of mice after being fed with HFD.
Identifiants
pubmed: 35919575
doi: 10.3746/pnf.2022.27.2.180
pii: pnfs-27-2-180
pmc: PMC9309068
doi:
Types de publication
Journal Article
Langues
eng
Pagination
180-187Informations de copyright
Copyright © 2022 by The Korean Society of Food Science and Nutrition. All rights Reserved.
Déclaration de conflit d'intérêts
AUTHOR DISCLOSURE STATEMENT The authors declare no conflict of interest.
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