Solution structure of a thrombin binding aptamer complex with a non-planar platinum(ii) compound.


Journal

Chemical science
ISSN: 2041-6520
Titre abrégé: Chem Sci
Pays: England
ID NLM: 101545951

Informations de publication

Date de publication:
20 Jul 2022
Historique:
received: 27 02 2022
accepted: 29 05 2022
entrez: 3 8 2022
pubmed: 4 8 2022
medline: 4 8 2022
Statut: epublish

Résumé

Thrombin Binding Aptamer (TBA) is a monomolecular well-defined two G-tetrad antiparallel G-quadruplex DNA that inhibits the activity of human α-thrombin. In this report, we synthesized a quasi-cross-shaped platinum(ii) compound (L'

Identifiants

pubmed: 35919711
doi: 10.1039/d2sc01196d
pii: d2sc01196d
pmc: PMC9297526
doi:

Types de publication

Journal Article

Langues

eng

Pagination

8371-8379

Informations de copyright

This journal is © The Royal Society of Chemistry.

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Bo-Chen Zhu (BC)

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University Guangzhou 510275 China cesmzw@mail.sysu.edu.cn liuwenting@mail.sysu.edu.cn xiawei5@mail.sysu.edu.cn.

Juan He (J)

School of Pharmaceutical and Chemical Engineering, Guangdong Pharmaceutical University Zhongshan 528458 China.

Xiao-Yu Xia (XY)

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University Guangzhou 510275 China cesmzw@mail.sysu.edu.cn liuwenting@mail.sysu.edu.cn xiawei5@mail.sysu.edu.cn.

Jingxing Jiang (J)

School of Materials Science and Engineering, PCFM Lab, School of Chemistry, Sun Yat-sen University Guangzhou 510275 China kezhf3@mail.sysu.edu.cn.

Wenting Liu (W)

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University Guangzhou 510275 China cesmzw@mail.sysu.edu.cn liuwenting@mail.sysu.edu.cn xiawei5@mail.sysu.edu.cn.

Liu-Yi Liu (LY)

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University Guangzhou 510275 China cesmzw@mail.sysu.edu.cn liuwenting@mail.sysu.edu.cn xiawei5@mail.sysu.edu.cn.

Bing-Bing Liang (BB)

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University Guangzhou 510275 China cesmzw@mail.sysu.edu.cn liuwenting@mail.sysu.edu.cn xiawei5@mail.sysu.edu.cn.

Hua-Gang Yao (HG)

School of Pharmaceutical and Chemical Engineering, Guangdong Pharmaceutical University Zhongshan 528458 China.

Zhuofeng Ke (Z)

School of Materials Science and Engineering, PCFM Lab, School of Chemistry, Sun Yat-sen University Guangzhou 510275 China kezhf3@mail.sysu.edu.cn.

Wei Xia (W)

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University Guangzhou 510275 China cesmzw@mail.sysu.edu.cn liuwenting@mail.sysu.edu.cn xiawei5@mail.sysu.edu.cn.

Zong-Wan Mao (ZW)

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University Guangzhou 510275 China cesmzw@mail.sysu.edu.cn liuwenting@mail.sysu.edu.cn xiawei5@mail.sysu.edu.cn.

Classifications MeSH