Mcm2 hypomorph leads to acute leukemia or hematopoietic stem cell failure, dependent on genetic context.
B-cell precursor acute lymphoblastic leukemia
DNA stress
Mcm2
bone marrow failure
tumor suppressor gene
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
revised:
07
06
2022
received:
25
01
2022
accepted:
13
06
2022
entrez:
3
8
2022
pubmed:
4
8
2022
medline:
5
8
2022
Statut:
ppublish
Résumé
Minichromosome maintenance proteins (Mcm2-7) form a hexameric complex that unwinds DNA ahead of a replicative fork. The deficiency of Mcm proteins leads to replicative stress and consequent genomic instability. Mice with a germline insertion of a Cre cassette into the 3'UTR of the Mcm2 gene (designated Mcm2
Identifiants
pubmed: 35920299
doi: 10.1096/fj.202200061RR
pmc: PMC9377154
mid: NIHMS1816637
doi:
Substances chimiques
Bcor protein, mouse
0
Mcm2 protein, mouse
0
Repressor Proteins
0
Transcription Factors
0
Minichromosome Maintenance Complex Component 2
EC 3.6.4.12
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e22430Subventions
Organisme : Intramural NIH HHS
ID : Z01 SC010378
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA SC010378
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA BC010982
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 BC010982
Pays : United States
Informations de copyright
© 2022 Federation of American Societies for Experimental Biology. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
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